Intestinal transport of cystine and cysteine in man: evidence for separate mechanisms

Cystine and cysteine are transported by energy-dependent, mediated processes in human gut. When either of these amino acids is transported, only cysteine is recovered intracellularly, indicating that cystine is reduced to cysteine after achieving an intracellular location. In contrast to results wit...

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Bibliographic Details
Published in:The Journal of clinical investigation 1967-01, Vol.46 (1), p.30-34
Main Authors: Rosenberg, L E, Crawhall, J C, Segal, S
Format: Article
Language:English
Subjects:
Arginine - metabolism
Biological Transport
Cysteine - metabolism
Cystine - metabolism
Cystinuria
Humans
Intestinal Mucosa - metabolism
Jejunum - metabolism
Lysine - metabolism
Radioisotopes
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Summary:Cystine and cysteine are transported by energy-dependent, mediated processes in human gut. When either of these amino acids is transported, only cysteine is recovered intracellularly, indicating that cystine is reduced to cysteine after achieving an intracellular location. In contrast to results with cystine, cysteine uptake is not defective in gut from cystinuric patients, nor do lysine and arginine compete with cysteine for transport. It is, therefore, concluded that cystine and cysteine are transported by different mechanisms, and that only the cystine transport mechanism is defective in cystinuria.
ISSN:0021-9738
DOI:10.1172/JCI105508