Evaluation of a Nanoemulsion-Based Formulation for Respiratory Delivery of Budesonide by Nebulizers

The aim of this work was to evaluate the in vitro performance of a nebulized nanoemulsion formulation which had been optimised previously. To do so, a transparent nanoemulsion preparation containing 1.5 mg/ml of budesonide was prepared and diluted to achieve concentrations of 250 and 500 μg/ml budes...

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Bibliographic Details
Published in:AAPS PharmSciTech 2010-09, Vol.11 (3), p.1147-1151
Main Authors: Amani, Amir, York, Peter, Chrystyn, Henry, Clark, Brian J.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Aerosols - administration & dosage
Aerosols - chemistry
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Drug Compounding - methods
Emulsions - chemical synthesis
Indexing in process
Materials Testing
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Nebulizers and Vaporizers
Pharmacology/Toxicology
Pharmacy
Research Article
Respiratory System Agents - administration & dosage
Respiratory System Agents - chemistry
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Summary:The aim of this work was to evaluate the in vitro performance of a nebulized nanoemulsion formulation which had been optimised previously. To do so, a transparent nanoemulsion preparation containing 1.5 mg/ml of budesonide was prepared and diluted to achieve concentrations of 250 and 500 μg/ml budesonide. The in vitro characteristics of the diluted nanoemulsions were then compared with the commercially available suspension of budesonide (Pulmicort Respules®) when nebulized using a jet and a vibrating mesh nebulizer. A smaller MMAD with improved aerosol output was observed in the nanoemulsion preparations compared with the corresponding suspension formulations indicating an improved in vitro performance for the nanoemulsion-based preparations.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-010-9486-9