Sleep depth and fatigue: Role of cellular inflammatory activation

Research highlights ► Individuals with underlying inflammation present with a high prevalence of non-specific co-morbid symptoms including sleep disturbance and fatigue. ► However, the association between cellular expression of proinflammatory cytokines, alterations of sleep depth and daytime fatigu...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2011-01, Vol.25 (1), p.53-58
Main Authors: Thomas, KaMala S, Motivala, S, Olmstead, R, Irwin, M.R
Format: Article
Language:English
Subjects:
Adult
Allergy and Immunology
Cellular inflammation
Cytokines - biosynthesis
Cytokines - blood
Fatigue
Fatigue - physiopathology
Female
Humans
Inflammation - physiopathology
Interleukin-6
Interleukin-6 - biosynthesis
Interleukin-6 - blood
Male
Middle Aged
Monocytes - metabolism
Polysomnography
Proinflammatory cytokines
Psychiatry
Rapid-eye movement sleep
Sleep - physiology
Sleep architecture
Sleep Stages - physiology
Sleep, REM - physiology
Slow wave sleep
Surveys and Questionnaires
Tumor Necrosis Factor-alpha - metabolism
Young Adult
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Summary:Research highlights ► Individuals with underlying inflammation present with a high prevalence of non-specific co-morbid symptoms including sleep disturbance and fatigue. ► However, the association between cellular expression of proinflammatory cytokines, alterations of sleep depth and daytime fatigue has not been concurrently examined. ► We report that evening stimulated monocyte production of interleukin-6 (IL-6), but not tumor necrosis factor a (TNF- a), was negatively associated with slow wave sleep in a sample of healthy adults. ► Moreover, evening stimulated production of IL-6 was associated with fatigue the following day. ► In contrast, stimulated monocyte production of IL-6 was positively associated with rapid-eye movement (REM) sleep duration during the first sleep cycle. ► These results indicate that increases in stimulated monocyte production of IL6 may be associated with decreases in slow wave sleep and increases in REM sleep duration. ► Relative loss of slow wave sleep may be one pathway through which cellular inflammation leads to daytime fatigue.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2010.07.245