Suppression of urinary and plasma follicle-stimulating hormone by exogenous estrogens in prepubertal and pubertal children

Clomiphene citrate, an "anti-estrogen" with mild estrogenic properties, inhibits rather than stimulates gonadotropin excretion in prepubertal and early pubertal children. These and other data suggest that the sensitivity of the hypothalamic-pituitary "gonadostat" decreases at the...

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Bibliographic Details
Published in:The Journal of clinical investigation 1973-05, Vol.52 (5), p.1122-1128
Main Authors: Kelch, R P, Kaplan, S L, Ghumbach, M M
Format: Article
Language:English
Subjects:
Adolescent
Child
Depression, Chemical
Estradiol - pharmacology
Estrogens - pharmacology
Estrone - blood
Ethinyl Estradiol - pharmacology
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Female
Follicle Stimulating Hormone - blood
Follicle Stimulating Hormone - secretion
Follicle Stimulating Hormone - urine
Growth Disorders - physiopathology
Humans
Hypothalamo-Hypophyseal System - drug effects
Luteinizing Hormone - blood
Luteinizing Hormone - secretion
Luteinizing Hormone - urine
Male
Puberty
Radioimmunoassay
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Summary:Clomiphene citrate, an "anti-estrogen" with mild estrogenic properties, inhibits rather than stimulates gonadotropin excretion in prepubertal and early pubertal children. These and other data suggest that the sensitivity of the hypothalamic-pituitary "gonadostat" decreases at the onset of puberty. To test this hypothesis further, the daily excretion of urinary follicle-stimulating hormone (FSH) and luteinizing hormone (LH) was determined in 19 children (5 "short normals" and 14 with isolated human growth hormone (HGH) deficiency) who were given ethinyl estradiol (EE) 1.4-14.7 mug/m(2) per day (2-10 mug/day) for 4 to 7 days. In addition, plasma and urinary gonadotropins and plasma estrogens were serially determined in two prepubertal females(with isolated HGH deficiency) given two injections (24 h apart) of estradiol benzoate, 10 mug/kg. FSH and LH concentrations in plasma and kaolin-acetone urinary concentrates and plasma 17beta-estradiol (E(2)) and estrone (E(1)) were measured by radioimmunoassays. 2-3 mug/m(2) per day of EE significantly suppressed urinary FSH (and LH when detected in the control period) in two out of six prepubertal children, while all doses >5 mug/m(2) per day suppressed urinary gonadotropins to undetectable levels in eight prepubertal subjects. In early to midpubertal subjects. 2-10 mug/m(2) per day of EE produced a slight suppression of urinary FSH, but failed to suppress to undetectable levels. Two subjects in late puberty (stage 4) did not suppress their urinary FSH while on 7 and 8.3 mug/m(2) per day. In both subjects treated with estradiol benzoate, plasma FSH promptly decreased after the first injection. Urinary FSH was suppressed to
ISSN:0021-9738
DOI:10.1172/JCI107278