Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2010-12, Vol.68 (6), p.1067-1081
Main Authors: Hoover, Brian R., Reed, Miranda N., Su, Jianjun, Penrod, Rachel D., Kotilinek, Linda A., Grant, Marianne K., Pitstick, Rose, Carlson, George A., Lanier, Lorene M., Yuan, Li-Lian, Ashe, Karen H., Liao, Dezhi
Format: Article
Language:English
Subjects:
Animals
Cancer
Cells, Cultured
Dendritic Spines - chemistry
Dendritic Spines - metabolism
Dendritic Spines - physiology
Memory
Memory Disorders - physiopathology
Mice
Mice, Transgenic
Nerve Degeneration - metabolism
Nerve Degeneration - physiopathology
Neurodegeneration
Neurons
Phosphorylation - physiology
Plasmids
Proteins
Rats
Rodents
Synapses - chemistry
Synapses - metabolism
Synapses - physiology
tau Proteins - metabolism
tau Proteins - physiology
Variance analysis
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Summary:The microtubule-associated protein tau accumulates in Alzheimer's and other fatal dementias, which manifest when forebrain neurons die. Recent advances in understanding these disorders indicate that brain dysfunction precedes neurodegeneration, but the role of tau is unclear. Here, we show that early tau-related deficits develop not from the loss of synapses or neurons, but rather as a result of synaptic abnormalities caused by the accumulation of hyperphosphorylated tau within intact dendritic spines, where it disrupts synaptic function by impairing glutamate receptor trafficking or synaptic anchoring. Mutagenesis of 14 disease-associated serine and threonine amino acid residues to create pseudohyperphosphorylated tau caused tau mislocalization while creation of phosphorylation-deficient tau blocked the mistargeting of tau to dendritic spines. Thus, tau phosphorylation plays a critical role in mediating tau mislocalization and subsequent synaptic impairment. These data establish that the locus of early synaptic malfunction caused by tau resides in dendritic spines. ► Tau proteins were aberrantly targeted to dendritic spines by the P301L mutation ► Phosphorylation controls tau mislocalization to dendritic spines ► Once mislocalized to spines, tau suppressed excitatory synaptic transmission ► Mislocalized tau proteins cause loss of surface AMPA receptors in spines
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2010.11.030