Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala

Despite considerable effort, the localization of dysfunction in major depressive disorder (MDD) remains poorly understood. We present a hypothesis about its localization that builds on recent findings from primate neuropsychology. The hypothesis has four key components: a deficit in the valuation of...

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Bibliographic Details
Published in:Biological psychiatry (1969) 2011-06, Vol.69 (12), p.e43-e54
Main Authors: Murray, Elisabeth A, Wise, Steven P, Drevets, Wayne C
Format: Article
Language:English
Subjects:
Amygdala - physiopathology
Animal models
Animals
Choice Behavior - physiology
Depressive Disorder, Major - physiopathology
Depressive Disorder, Major - psychology
devaluation
Ego
emotion
Emotions - physiology
Frontal Lobe - physiopathology
frontal lobe function
Humans
mood
Prefrontal Cortex - physiopathology
primate research
Psychiatry
Psychomotor Performance - physiology
reversal
Reversal Learning - physiology
reward
Self Concept
self-esteem
self-reflection
self-valuation
self-worth
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Summary:Despite considerable effort, the localization of dysfunction in major depressive disorder (MDD) remains poorly understood. We present a hypothesis about its localization that builds on recent findings from primate neuropsychology. The hypothesis has four key components: a deficit in the valuation of “self” underlies the core disorder in MDD; the medial frontal cortex represents “self”; interactions between the amygdala and cortical representations update their valuation; and inefficiency in using positive feedback by orbital prefrontal cortex contributes to MDD.
ISSN:0006-3223
1873-2402
DOI:10.1016/j.biopsych.2010.09.041