Parvovirus B19 infection in human pregnancy

Please cite this paper as: Lamont R, Sobel J, Vaisbuch E, Kusanovic J, Mazaki‐Tovi S, Kim S, Uldbjerg N, Romero R. Parvovirus B19 infection in human pregnancy. BJOG 2011;118:175–186. Human parvovirus B19 infection is widespread. Approximately 30–50% of pregnant women are nonimmune, and vertical tran...

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Published in:BJOG : an international journal of obstetrics and gynaecology 2011-01, Vol.118 (2), p.175-186
Main Authors: Lamont, RF, Sobel, JD, Vaisbuch, E, Kusanovic, JP, Mazaki‐Tovi, S, Kim, SK, Uldbjerg, N, Romero, R
Format: Article
Language:English
Subjects:
Erythema Infectiosum - diagnosis
Erythema Infectiosum - epidemiology
Erythema Infectiosum - therapy
Female
Fetal anaemia
Fetal Diseases - diagnosis
Fetal Diseases - epidemiology
Fetal Diseases - therapy
Fetal Monitoring
Fetuses
human
Humans
hydrops‐fetalis
Medical screening
nonimmune hydrops
parvovirus
Parvovirus B19, Human
Pregnancy
Pregnancy Complications, Infectious - diagnosis
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - therapy
Viruses
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Summary:Please cite this paper as: Lamont R, Sobel J, Vaisbuch E, Kusanovic J, Mazaki‐Tovi S, Kim S, Uldbjerg N, Romero R. Parvovirus B19 infection in human pregnancy. BJOG 2011;118:175–186. Human parvovirus B19 infection is widespread. Approximately 30–50% of pregnant women are nonimmune, and vertical transmission is common following maternal infection in pregnancy. Fetal infection may be associated with a normal outcome, but fetal death may also occur without ultrasound evidence of infectious sequelae. B19 infection should be considered in any case of nonimmune hydrops. Diagnosis is mainly through serology and polymerase chain reaction. Surveillance requires sequential ultrasound and Doppler screening for signs of fetal anaemia, heart failure and hydrops. Immunoglobulins, antiviral and vaccination are not yet available, but intrauterine transfusion in selected cases can be life saving.
ISSN:1470-0328
1471-0528
DOI:10.1111/j.1471-0528.2010.02749.x