Expression of mast cell–associated genes is upregulated in adult eosinophilic esophagitis and responds to steroid or dietary therapy

• Published in: Journal of allergy and clinical immunology 2011-05, Vol.127 (5), p.1307-1308.e3
• Main Authors: Hsu Blatman, Karen S., MD, Gonsalves, Nirmala, MD, Hirano, Ikuo, MD, Bryce, Paul J., PhD
• Format: Article
• Language: English
• Subjects: Adult; Age; Aged; Aged, 80 and over; Allergies; Allergy and Immunology; Androstadienes - pharmacology; Androstadienes - therapeutic use; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Biological and medical sciences; Biopsy; Carboxypeptidases A - genetics; Carboxypeptidases A - metabolism; Chemokine CCL26; Chemokines, CC - genetics; Chemokines, CC - metabolism; Dysphagia; Endoscopy; Eosinophilic Esophagitis - diet therapy; Eosinophilic Esophagitis - drug therapy; Eosinophilic Esophagitis - immunology; Eosinophilic Esophagitis - physiopathology; Esophagus; Female; Fluticasone; Food; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gastroenterology. Liver. Pancreas. Abdomen; Gene expression; Gene Expression - drug effects; Humans; Immunopathology; Male; Mast Cells - immunology; Mast Cells - metabolism; Medical sciences; Middle Aged; Other diseases. Semiology; Pathogenesis; Pediatrics; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Steroids - pharmacology; Steroids - therapeutic use; Studies; Treatment Outcome; Up-Regulation
• ISSN: 0091-6749; 1097-6825
• DOI: 10.1016/j.jaci.2010.12.1118

Biopsy specimens from 7 patients without EoE (3 male and 4 female patients; median age, 54 years; age range, 27-80 years; average peak eosinophil count, 0) and from 21 patients with EoE (17 male and 4 female patients; median age, 40 years; age range, 28-84 years; average peak eosinophil count, 41.3) were studied for expression of several well-defined mast cell-associated genes: the β chain of the high-affinity IgE receptor (FCERIB), the histamine-synthesizing enzyme histidine decarboxylase (HDC), and 2 mast cell-specific proteases: tryptase α/β1 (TPSAB1) and carboxypeptidase (CPA3). [...]mast cells might be an important target for treatment of both pediatric and adult disease.