Targeted mini-strokes produce changes in interhemispheric sensory signal processing that are indicative of disinhibition within minutes

Most processing of sensation involves the cortical hemisphere opposite (contralateral) to the stimulated limb. Stroke patients can exhibit changes in the interhemispheric balance of sensory signal processing. It is unclear whether these changes are the result of poststroke rewiring and experience, o...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2011-05, Vol.108 (22), p.E183-E191
Main Authors: Mohajerani, Majid H, Aminoltejari, Khatereh, Murphy, Timothy H
Format: Article
Language:English
Subjects:
Animals
arterioles
Biological Sciences
Brain
Cells
cortex
Disease Models, Animal
Forelimb - pathology
Forelimb - physiopathology
image analysis
Male
Mice
Mice, Inbred C57BL
Models, Biological
monitoring
Neuronal Plasticity
patients
Pharmacology
Physiology
Pia Mater - metabolism
PNAS Plus
Rodents
sensation
Sensory perception
Somatosensory Cortex - physiology
Stroke
Stroke - physiopathology
Tetrodotoxin - pharmacology
thalamus
Thalamus - physiology
Voltage-Sensitive Dye Imaging - methods
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Summary:Most processing of sensation involves the cortical hemisphere opposite (contralateral) to the stimulated limb. Stroke patients can exhibit changes in the interhemispheric balance of sensory signal processing. It is unclear whether these changes are the result of poststroke rewiring and experience, or whether they could result from the immediate effect of circuit loss. We evaluated the effect of mini-strokes over short timescales (
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1101914108