Time trends in oral clefts in Chinese newborns: Data from the Chinese National Birth Defects Monitoring Network

BACKGROUND: Although the prevalence of oral clefts in China is among the highest in countries worldwide, little is known about its descriptive epidemiology. METHODS: Data used in this study were collected from 1996 to 2005 using the nationwide hospital‐based registry, the Chinese Birth Defects Monit...

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Published in:Birth defects research. A Clinical and molecular teratology 2010-01, Vol.88 (1), p.41-47
Main Authors: Dai, Li, Zhu, Jun, Mao, Meng, Li, Yanhua, Deng, Ying, Wang, Yanping, Liang, Juan, Tang, Liu, Wang, He, Kilfoy, Briseis A., Zheng, Tongzhang, Zhang, Yawei
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group - ethnology
Asian Continental Ancestry Group - statistics & numerical data
birth defects
China - epidemiology
cleft lip
Cleft Lip - epidemiology
cleft lip and palate
cleft palate
Cleft Palate - epidemiology
Female
Humans
Infant, Newborn
Medical Records
Neonatal Screening
oral clefts
Pregnancy
Pregnancy Outcome
Prevalence
Registries
Time Factors
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Summary:BACKGROUND: Although the prevalence of oral clefts in China is among the highest in countries worldwide, little is known about its descriptive epidemiology. METHODS: Data used in this study were collected from 1996 to 2005 using the nationwide hospital‐based registry, the Chinese Birth Defects Monitoring Network. A total of 4,891,472 newborns (live or still births with 28 weeks of gestation or more) delivered in member hospitals were assessed for birth defects within 7 days following birth. RESULTS: The prevalence of nonsyndromic, syndromic, and overall clefts was 14.23, 2.40, and 16.63 per 10,000, respectively. An upward time trend in the prevalence of nonsyndromic cleft palate and nonsyndromic cleft lip was detected. Cleft lip with or without cleft palate showed a different pattern by gender, urban‐rural classification, and geographic location when compared to cleft palate, particularly for nonsyndromic cases. Maternal age was associated with prevalence of all oral clefts. Neonates with oral clefts had increased rates of mortality. CONCLUSIONS: The observed complex patterns of prevalence of oral clefts from the Chinese national birth defects registry indicate that oral cleft subtypes by either cleft location or syndromic status should be considered in the development of intervention measures and in future analytical studies. Birth Defects Research (Part A), 2010. © 2009 Wiley‐Liss, Inc.
ISSN:1542-0752
1542-0760
DOI:10.1002/bdra.20607