Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene

Vertebrate genomes contain multiple copies of related genes that arose through gene duplication. In the past it has been proposed that these duplicated genes were retained because of acquisition of novel beneficial functions. A more recent model, the duplication-degeneration-complementation hypothes...

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Bibliographic Details
Published in:Genome research 2001-10, Vol.11 (10), p.1625-1631
Main Authors: Serluca, F C, Sidow, A, Mably, J D, Fishman, M C
Format: Article
Language:English
Subjects:
Amino Acid Sequence - genetics
Animals
Danio rerio
engrailed gene
Evolution, Molecular
Gene Duplication
Gene Expression Regulation, Enzymologic - genetics
Gene Order
Letter
Molecular Sequence Data
Organ Specificity - genetics
Phylogeny
Protein Isoforms - biosynthesis
Protein Isoforms - genetics
Radiation Hybrid Mapping - methods
Sequence Homology, Amino Acid
Sodium-Potassium-Exchanging ATPase - biosynthesis
Sodium-Potassium-Exchanging ATPase - genetics
sox gene
Zebrafish
Zebrafish Proteins
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Summary:Vertebrate genomes contain multiple copies of related genes that arose through gene duplication. In the past it has been proposed that these duplicated genes were retained because of acquisition of novel beneficial functions. A more recent model, the duplication-degeneration-complementation hypothesis (DDC), posits that the functions of a single gene may become separately allocated among the duplicated genes, rendering both duplicates essential. Thus far, empirical evidence for this model has been limited to the engrailed and sox family of developmental regulators, and it has been unclear whether it may also apply to ubiquitously expressed genes with essential functions for cell survival. Here we describe the cloning of three zebrafish alpha subunits of the Na(+),K(+)-ATPase and a comprehensive evolutionary analysis of this gene family. The predicted amino acid sequences are extremely well conserved among vertebrates. The evolutionary relationships and the map positions of these genes and of other alpha-like sequences indicate that both tandem and ploidy duplications contributed to the expansion of this gene family in the teleost lineage. The duplications are accompanied by acquisition of clear functional specialization, consistent with the DDC model of genome evolution.
ISSN:1088-9051
1054-9803
1549-5469
DOI:10.1101/gr.192001