No evidence of association between 118A>G OPRM1 polymorphism and heroin dependence in a large Bulgarian case–control sample

Abstract The μ-opioid receptor is the primary site of action of most opioids. The 118A>G (rs1799971) polymorphism in exon 1 of the μ-opioid receptor gene ( OPRM1 ) leads to an Asn40Asp amino acid change that affects a putative N-glycosylation site. It has been widely investigated for association...

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Published in:Drug and alcohol dependence 2011-08, Vol.117 (1), p.62-65
Main Authors: Nikolov, Momchil A, Beltcheva, Olga, Galabova, Antoaneta, Ljubenova, Anna, Jankova, Elena, Gergov, Galin, Russev, Atanas A, Lynskey, Michael T, Nelson, Elliot C, Nesheva, Eleonora, Krasteva, Dorita, Lazarov, Philip, Mitev, Vanio I, Kremensky, Ivo M, Kaneva, Radka P, Todorov, Alexandre A
Format: Article
Language:English
Subjects:
118A>G
Addictive behaviors
Adult
Adult and adolescent clinical studies
Alleles
Analgesics, Opioid - metabolism
Association
Biological and medical sciences
Bulgaria - epidemiology
Bulgaria - ethnology
Case-Control Studies
Drug addiction
Exons
Female
Genotype
Heroin dependence
Heroin Dependence - genetics
Heroin Dependence - physiopathology
Humans
Male
Medical sciences
OPRM1
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Opioid, mu - genetics
Receptors, Opioid, mu - physiology
Risk Factors
Romania - ethnology
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Summary:Abstract The μ-opioid receptor is the primary site of action of most opioids. The 118A>G (rs1799971) polymorphism in exon 1 of the μ-opioid receptor gene ( OPRM1 ) leads to an Asn40Asp amino acid change that affects a putative N-glycosylation site. It has been widely investigated for association with alcohol and drug dependence and pain sensitivity, with mixed results. The aim of the current study was to examine whether this polymorphism was associated with heroin dependence in a large Bulgarian cohort of 1842 active users and 1451 population controls. SNP genotyping was done using Real-Time PCR TaqMan technology. Association analyses were conducted, separately for Roma and non-Roma participants. Our results suggest that there is no direct effect of 118A>G genotype on the risk for heroin dependence among active heroin users.
ISSN:0376-8716
1879-0046
1879-0046
DOI:10.1016/j.drugalcdep.2010.12.026