GST polymorphisms are associated with hepatocellular carcinoma risk in Chinese population

• Published in: World journal of gastroenterology : WJG 2011-07, Vol.17 (27), p.3248-3256
• Main Authors: Yu, Lei, Wang, Chun-Yu, Xi, Bo, Sun, Lei, Wang, Ruo-Qi, Yan, Yin-Kun, Zhu, Li-Ying
• Format: Article
• Language: English
• Subjects: Asian Continental Ancestry Group; Brief; Carcinoma, Hepatocellular - ethnology; Carcinoma, Hepatocellular - genetics; Case-Control Studies; China; Genetic Predisposition to Disease; Glutathione Transferase - genetics; Glutathione Transferase - metabolism; GST; Humans; Liver Neoplasms - ethnology; Liver Neoplasms - genetics; Models, Statistical; null; Odds Ratio; Polymorphism, Genetic; 中国人口; 危险性; 固定效应模型; 基因多态性; 敏感性分析; 肝癌
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v17.i27.3248

AIM： To investigate the association between GSTM1 and GSTT1 polymorphisms and the risk of hepatocellular carcinoma （HCC） in Chinese population. METHODS： Literature databases including PubMed, ISI web of science and other databases were searched.Pooled odds ratio （OR） and 95% CI were calculated using random- or fixed-effects model. Subgroup analysis and sensitivity analysis were also performed. RESULTS： Nineteen studies of GSTM1 （2660 cases and 4017 controls） and 16 studies of GSTT1 （2410 cases and 3669 controls） were included. The GSTM1/GSTT1 null genotypes were associated with increased risk of HCC in Chinese population （for GSTM1, OR = 1.487, 95% CI： 1.159 to 1.908, P = 0.002; for GSTT1, OR = 1.510, 95% CI： 1.236 to 1.845, P = 0.000）. No publication bias was detected. In subgroup analysis, glutathione S-transferases polymorphisms were significantly associated with HCC risk among the subjects living in high-incidence areas, but not among the subjects living in low-incidence areas. CONCLUSION： The present meta-analysis suggests that GSTM1/GSTT1 null genotypes are associated with increased risk of HCC in Chinese population.