Adolescent Binge Drinking Linked to Abnormal Spatial Working Memory Brain Activation: Differential Gender Effects

Background:  Binge drinking is prevalent during adolescence, and its effect on neurocognitive development is of concern. In adult and adolescent populations, heavy substance use has been associated with decrements in cognitive functioning, particularly on tasks of spatial working memory (SWM). Chara...

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Published in:Alcoholism, clinical and experimental research clinical and experimental research, 2011-10, Vol.35 (10), p.1831-1841
Main Authors: Squeglia, Lindsay M., Schweinsburg, Alecia Dager, Pulido, Carmen, Tapert, Susan F.
Format: Article
Language:English
Subjects:
Addictive behaviors
Adolescence
Adolescent
Adult and adolescent clinical studies
Affect - physiology
Alcohol
Alcohol Drinking - epidemiology
Alcohol Drinking - physiopathology
Alcohol Drinking - psychology
Alcoholism
Alcoholism and acute alcohol poisoning
Attention - drug effects
Binge
Biological and medical sciences
Brain - physiopathology
Breath Tests
Central Nervous System Depressants - pharmacology
Central Nervous System Depressants - poisoning
Central Nervous System Depressants - toxicity
Cognition - physiology
Ethanol - pharmacology
Ethanol - poisoning
Ethanol - toxicity
Female
fMRI
Gender
Humans
Magnetic Resonance Imaging - methods
Male
Medical sciences
Memory Disorders - chemically induced
Memory Disorders - epidemiology
Memory Disorders - physiopathology
Memory, Short-Term - physiology
Neuropsychological Tests
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance - physiology
Psychopathology. Psychiatry
Sex Factors
Toxicology
Young Adult
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Summary:Background:  Binge drinking is prevalent during adolescence, and its effect on neurocognitive development is of concern. In adult and adolescent populations, heavy substance use has been associated with decrements in cognitive functioning, particularly on tasks of spatial working memory (SWM). Characterizing the gender‐specific influences of heavy episodic drinking on SWM may help elucidate the early functional consequences of drinking on adolescent brain functioning. Methods:  Forty binge drinkers (13 females, 27 males) and 55 controls (24 females, 31 males), aged 16 to 19 years, completed neuropsychological testing, substance use interviews, and an SWM task during functional magnetic resonance imaging. Results:  Significant binge drinking status × gender interactions were found (p 
ISSN:0145-6008
1530-0277
DOI:10.1111/j.1530-0277.2011.01527.x