Resolution of diabetes mellitus by ileal transposition compared with biliopancreatic diversion in a nonobese animal model of type 2 diabetes

Background It has been demonstrated that biliopancreatic diversion (BPD) and ileal transposition (IT) effectively induce weight loss and long-term control of type 2 diabetes in morbidly obese individuals. It is unknown whether the control of diabetes is better after IT or after BPD. The objective of...

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Bibliographic Details
Published in:Canadian Journal of Surgery 2011-08, Vol.54 (4), p.243-251
Main Authors: Zhang, Guang Yong, PhD, Wang, Tian Tian, PhD, Cheng, Zhi Qiang, PhD, Feng, Jin Bo, MD, Hu, San Yuau, MD
Format: Article
Language:English
Subjects:
Anastomosis, Surgical
Animals
Biliopancreatic Diversion
Blood Glucose - metabolism
Care and treatment
Diabetes
Diabetes Mellitus, Experimental - metabolism
Diabetes Mellitus, Experimental - surgery
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - surgery
Gastrointestinal surgery
Glucagon-Like Peptide 1 - metabolism
Ileum - surgery
Insulin
Insulin Resistance - physiology
Male
Medical treatment
Obesity
Physiological aspects
Rats
Rodents
Studies
Surgery
Type 2 diabetes
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Summary:Background It has been demonstrated that biliopancreatic diversion (BPD) and ileal transposition (IT) effectively induce weight loss and long-term control of type 2 diabetes in morbidly obese individuals. It is unknown whether the control of diabetes is better after IT or after BPD. The objective of this study was to investigate the effects of IT and BPD on the control of diabetes in an animal model. Methods We performed IT and BPD on 10- to 12-week-old Goto–Kakizaki rats with a spontaneous nonobese model of type 2 diabetes, and we performed a series of detection. The rats were observed for 24 weeks after surgery. Results Animals who underwent IT and BPD demonstrated improved glucose tolerance, insulin sensitivity and the secretion of glucagon-like peptide-1 compared with the sham-operated animals. Furthermore, IT resulted in a shorter duration of surgery and better postoperative recovery than BPD. Conclusion This study provides strong evidence for the crucial role of the hindgut in the resolution of diabetes after duodenum-jejunum bypass or IT. We confirmed that IT was associated with better postoperative recovery than BPD and had a similar control of diabetes as BPD in nonobese animals with type 2 diabetes.
ISSN:0008-428X
1488-2310
DOI:10.1503/cjs.044209