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Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study
Aims To investigate the role of medication in 20-year trends in blood pressure (BP) and blood lipids in older British men. Methods and results BP and lipids were measured in 4231 men from a representative cohort at baseline (1978–1980, aged 40–59 years) and after 20 years (1998–2000). Cohort-wide ag...
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| Published in: | European journal of cardiovascular prevention and rehabilitation 2010-10, Vol.17 (5), p.502-508 |
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| container_title | European journal of cardiovascular prevention and rehabilitation |
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| creator | Hardoon, Sarah L. Whincup, Peter H. Goya Wannamethee, S. Lennon, Lucy T. Capewell, Simon Morris, Richard W. |
| description | Aims
To investigate the role of medication in 20-year trends in blood pressure (BP) and blood lipids in older British men. Methods and results BP and lipids were measured in 4231 men from a representative cohort at baseline (1978–1980, aged 40–59 years) and after 20 years (1998–2000). Cohort-wide age-adjusted 20-year mean changes were as follows: systolic BP – 7.6mmHg (95% confidence interval: – 9.7 to – 5.4); diastolic BP + 3.3mmHg (+2.2 to + 4.5); nonhigh-density lipoprotein (HDL)-cholesterol – 0.4 mmol/l (– 0.5 to – 0.2); HDL-cholesterol +0.16 mmol/l (+ 0.13 to + 0.19). Much (79%) of the systolic BP fall occurred only among 1561 men (37%) reporting the use of BP-lowering medication during the follow-up; systolic BP changed by – 12.3mmHg (− 14.7 to – 9.9) and – 1.6mmHg (– 3.7 to + 0.5) among medication users and men not using medication, respectively (P |
| doi_str_mv | 10.1097/HJR.0b013e3283378865 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3194092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1097_HJR.0b013e3283378865</sage_id><sourcerecordid>756666640</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-63e507fe0d5ed7795c694af88ab72d173bf5bdeaef5d3b29d41af15e672006d33</originalsourceid><addsrcrecordid>eNp9UU1v1DAQtRAVrdr-A4R847TFH3HscEAqFVBQpUoIzpYTT3a9JPbicSr13-OyZQUcOpcZad578_EIecnZBWedfnP95esF6xmXIIWRUhvTqmfkRLBGrxpj-PNDreUxOUfcshotE8KYF-RYMGlayfkJKZeIgBjimpYN0DDv3FBoGukMPgyuhBTpgkBrKhmiRxoind02ZTqknKLL9zQH_EHHykv5dztNHjJ9n0MJuKlC8S11Fb1JuVAsi78_I0ejmxDOH_Mp-f7xw7er69XN7afPV5c3q0FxVVatBMX0CMwr8Fp3ami7xo3GuF4Lz7XsR9V7cDAqL3vR-Ya7kStotai3eilPybu97m7p6z0DxJLdZHc5zHVvm1yw_3Zi2Nh1urOSdw3rRBV4_SiQ088FsNg54ADT5CKkBa1W7UM0rCKbPXLICTHDeJjCmX2wzFbL7P-WVdqrvzc8kP4YVAF8D0C3BrtNS471Y0-L_gJAraQZ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>756666640</pqid></control><display><type>article</type><title>Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study</title><source>Oxford Journals Online</source><creator>Hardoon, Sarah L. ; Whincup, Peter H. ; Goya Wannamethee, S. ; Lennon, Lucy T. ; Capewell, Simon ; Morris, Richard W.</creator><creatorcontrib>Hardoon, Sarah L. ; Whincup, Peter H. ; Goya Wannamethee, S. ; Lennon, Lucy T. ; Capewell, Simon ; Morris, Richard W.</creatorcontrib><description>Aims
To investigate the role of medication in 20-year trends in blood pressure (BP) and blood lipids in older British men. Methods and results BP and lipids were measured in 4231 men from a representative cohort at baseline (1978–1980, aged 40–59 years) and after 20 years (1998–2000). Cohort-wide age-adjusted 20-year mean changes were as follows: systolic BP – 7.6mmHg (95% confidence interval: – 9.7 to – 5.4); diastolic BP + 3.3mmHg (+2.2 to + 4.5); nonhigh-density lipoprotein (HDL)-cholesterol – 0.4 mmol/l (– 0.5 to – 0.2); HDL-cholesterol +0.16 mmol/l (+ 0.13 to + 0.19). Much (79%) of the systolic BP fall occurred only among 1561 men (37%) reporting the use of BP-lowering medication during the follow-up; systolic BP changed by – 12.3mmHg (− 14.7 to – 9.9) and – 1.6mmHg (– 3.7 to + 0.5) among medication users and men not using medication, respectively (P <0.001 for medication–time interaction). One-third of the non-HDL-cholesterol fall occurred only among 302 men (8%) reporting the use of lipid-regulating drugs; non- HDL-cholesterol changed by – 1.8 mmol/l (– 2.0 to – 1.6) and – 0.2 mmol/l (– 0.4 to – 0.1) among medication users and men not using medication, respectively (P <0.001 for interaction). The HDL-cholesterol increase was not associated with lipid-regulating drug use (P = 0.15 for interaction).
Conclusion
Decreases in BP were largely confined to medication users and overall changes in non-HDL-cholesterol were modest, suggesting the need for greater efforts to reduce BP and cholesterol among the general population. HDL-cholesterol increased among all men, likely reflecting cohort-wide improvements in associated health behaviours.</description><identifier>ISSN: 2047-4873</identifier><identifier>ISSN: 1741-8267</identifier><identifier>ISSN: 1741-8275</identifier><identifier>EISSN: 2047-4881</identifier><identifier>EISSN: 1741-8275</identifier><identifier>DOI: 10.1097/HJR.0b013e3283378865</identifier><identifier>PMID: 20386311</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adult ; Age Factors ; Antihypertensive Agents - therapeutic use ; Biomarkers - blood ; Blood Pressure - drug effects ; Cholesterol - blood ; Cholesterol, HDL - blood ; Cohort Studies ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - etiology ; Coronary Artery Disease - prevention & control ; Drug Utilization ; Dyslipidemias - blood ; Dyslipidemias - complications ; Dyslipidemias - drug therapy ; Dyslipidemias - epidemiology ; Health Behavior ; Humans ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - epidemiology ; Hypertension - physiopathology ; Hypolipidemic Agents - therapeutic use ; Linear Models ; Male ; Middle Aged ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; United Kingdom - epidemiology</subject><ispartof>European journal of cardiovascular prevention and rehabilitation, 2010-10, Vol.17 (5), p.502-508</ispartof><rights>2010 European Society of Cardiology</rights><rights>2010 The European Society of Cardiology 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-63e507fe0d5ed7795c694af88ab72d173bf5bdeaef5d3b29d41af15e672006d33</citedby><cites>FETCH-LOGICAL-c515t-63e507fe0d5ed7795c694af88ab72d173bf5bdeaef5d3b29d41af15e672006d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20386311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hardoon, Sarah L.</creatorcontrib><creatorcontrib>Whincup, Peter H.</creatorcontrib><creatorcontrib>Goya Wannamethee, S.</creatorcontrib><creatorcontrib>Lennon, Lucy T.</creatorcontrib><creatorcontrib>Capewell, Simon</creatorcontrib><creatorcontrib>Morris, Richard W.</creatorcontrib><title>Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study</title><title>European journal of cardiovascular prevention and rehabilitation</title><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><description>Aims
To investigate the role of medication in 20-year trends in blood pressure (BP) and blood lipids in older British men. Methods and results BP and lipids were measured in 4231 men from a representative cohort at baseline (1978–1980, aged 40–59 years) and after 20 years (1998–2000). Cohort-wide age-adjusted 20-year mean changes were as follows: systolic BP – 7.6mmHg (95% confidence interval: – 9.7 to – 5.4); diastolic BP + 3.3mmHg (+2.2 to + 4.5); nonhigh-density lipoprotein (HDL)-cholesterol – 0.4 mmol/l (– 0.5 to – 0.2); HDL-cholesterol +0.16 mmol/l (+ 0.13 to + 0.19). Much (79%) of the systolic BP fall occurred only among 1561 men (37%) reporting the use of BP-lowering medication during the follow-up; systolic BP changed by – 12.3mmHg (− 14.7 to – 9.9) and – 1.6mmHg (– 3.7 to + 0.5) among medication users and men not using medication, respectively (P <0.001 for medication–time interaction). One-third of the non-HDL-cholesterol fall occurred only among 302 men (8%) reporting the use of lipid-regulating drugs; non- HDL-cholesterol changed by – 1.8 mmol/l (– 2.0 to – 1.6) and – 0.2 mmol/l (– 0.4 to – 0.1) among medication users and men not using medication, respectively (P <0.001 for interaction). The HDL-cholesterol increase was not associated with lipid-regulating drug use (P = 0.15 for interaction).
Conclusion
Decreases in BP were largely confined to medication users and overall changes in non-HDL-cholesterol were modest, suggesting the need for greater efforts to reduce BP and cholesterol among the general population. HDL-cholesterol increased among all men, likely reflecting cohort-wide improvements in associated health behaviours.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Biomarkers - blood</subject><subject>Blood Pressure - drug effects</subject><subject>Cholesterol - blood</subject><subject>Cholesterol, HDL - blood</subject><subject>Cohort Studies</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - etiology</subject><subject>Coronary Artery Disease - prevention & control</subject><subject>Drug Utilization</subject><subject>Dyslipidemias - blood</subject><subject>Dyslipidemias - complications</subject><subject>Dyslipidemias - drug therapy</subject><subject>Dyslipidemias - epidemiology</subject><subject>Health Behavior</subject><subject>Humans</subject><subject>Hypertension - complications</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - epidemiology</subject><subject>Hypertension - physiopathology</subject><subject>Hypolipidemic Agents - therapeutic use</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>United Kingdom - epidemiology</subject><issn>2047-4873</issn><issn>1741-8267</issn><issn>1741-8275</issn><issn>2047-4881</issn><issn>1741-8275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9UU1v1DAQtRAVrdr-A4R847TFH3HscEAqFVBQpUoIzpYTT3a9JPbicSr13-OyZQUcOpcZad578_EIecnZBWedfnP95esF6xmXIIWRUhvTqmfkRLBGrxpj-PNDreUxOUfcshotE8KYF-RYMGlayfkJKZeIgBjimpYN0DDv3FBoGukMPgyuhBTpgkBrKhmiRxoind02ZTqknKLL9zQH_EHHykv5dztNHjJ9n0MJuKlC8S11Fb1JuVAsi78_I0ejmxDOH_Mp-f7xw7er69XN7afPV5c3q0FxVVatBMX0CMwr8Fp3ami7xo3GuF4Lz7XsR9V7cDAqL3vR-Ya7kStotai3eilPybu97m7p6z0DxJLdZHc5zHVvm1yw_3Zi2Nh1urOSdw3rRBV4_SiQ088FsNg54ADT5CKkBa1W7UM0rCKbPXLICTHDeJjCmX2wzFbL7P-WVdqrvzc8kP4YVAF8D0C3BrtNS471Y0-L_gJAraQZ</recordid><startdate>20101001</startdate><enddate>20101001</enddate><creator>Hardoon, Sarah L.</creator><creator>Whincup, Peter H.</creator><creator>Goya Wannamethee, S.</creator><creator>Lennon, Lucy T.</creator><creator>Capewell, Simon</creator><creator>Morris, Richard W.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20101001</creationdate><title>Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study</title><author>Hardoon, Sarah L. ; Whincup, Peter H. ; Goya Wannamethee, S. ; Lennon, Lucy T. ; Capewell, Simon ; Morris, Richard W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-63e507fe0d5ed7795c694af88ab72d173bf5bdeaef5d3b29d41af15e672006d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Biomarkers - blood</topic><topic>Blood Pressure - drug effects</topic><topic>Cholesterol - blood</topic><topic>Cholesterol, HDL - blood</topic><topic>Cohort Studies</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - etiology</topic><topic>Coronary Artery Disease - prevention & control</topic><topic>Drug Utilization</topic><topic>Dyslipidemias - blood</topic><topic>Dyslipidemias - complications</topic><topic>Dyslipidemias - drug therapy</topic><topic>Dyslipidemias - epidemiology</topic><topic>Health Behavior</topic><topic>Humans</topic><topic>Hypertension - complications</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - epidemiology</topic><topic>Hypertension - physiopathology</topic><topic>Hypolipidemic Agents - therapeutic use</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hardoon, Sarah L.</creatorcontrib><creatorcontrib>Whincup, Peter H.</creatorcontrib><creatorcontrib>Goya Wannamethee, S.</creatorcontrib><creatorcontrib>Lennon, Lucy T.</creatorcontrib><creatorcontrib>Capewell, Simon</creatorcontrib><creatorcontrib>Morris, Richard W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of cardiovascular prevention and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hardoon, Sarah L.</au><au>Whincup, Peter H.</au><au>Goya Wannamethee, S.</au><au>Lennon, Lucy T.</au><au>Capewell, Simon</au><au>Morris, Richard W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study</atitle><jtitle>European journal of cardiovascular prevention and rehabilitation</jtitle><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><date>2010-10-01</date><risdate>2010</risdate><volume>17</volume><issue>5</issue><spage>502</spage><epage>508</epage><pages>502-508</pages><issn>2047-4873</issn><issn>1741-8267</issn><issn>1741-8275</issn><eissn>2047-4881</eissn><eissn>1741-8275</eissn><abstract>Aims
To investigate the role of medication in 20-year trends in blood pressure (BP) and blood lipids in older British men. Methods and results BP and lipids were measured in 4231 men from a representative cohort at baseline (1978–1980, aged 40–59 years) and after 20 years (1998–2000). Cohort-wide age-adjusted 20-year mean changes were as follows: systolic BP – 7.6mmHg (95% confidence interval: – 9.7 to – 5.4); diastolic BP + 3.3mmHg (+2.2 to + 4.5); nonhigh-density lipoprotein (HDL)-cholesterol – 0.4 mmol/l (– 0.5 to – 0.2); HDL-cholesterol +0.16 mmol/l (+ 0.13 to + 0.19). Much (79%) of the systolic BP fall occurred only among 1561 men (37%) reporting the use of BP-lowering medication during the follow-up; systolic BP changed by – 12.3mmHg (− 14.7 to – 9.9) and – 1.6mmHg (– 3.7 to + 0.5) among medication users and men not using medication, respectively (P <0.001 for medication–time interaction). One-third of the non-HDL-cholesterol fall occurred only among 302 men (8%) reporting the use of lipid-regulating drugs; non- HDL-cholesterol changed by – 1.8 mmol/l (– 2.0 to – 1.6) and – 0.2 mmol/l (– 0.4 to – 0.1) among medication users and men not using medication, respectively (P <0.001 for interaction). The HDL-cholesterol increase was not associated with lipid-regulating drug use (P = 0.15 for interaction).
Conclusion
Decreases in BP were largely confined to medication users and overall changes in non-HDL-cholesterol were modest, suggesting the need for greater efforts to reduce BP and cholesterol among the general population. HDL-cholesterol increased among all men, likely reflecting cohort-wide improvements in associated health behaviours.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>20386311</pmid><doi>10.1097/HJR.0b013e3283378865</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of cardiovascular prevention and rehabilitation, 2010-10, Vol.17 (5), p.502-508 |
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| source | Oxford Journals Online |
| subjects | Adult Age Factors Antihypertensive Agents - therapeutic use Biomarkers - blood Blood Pressure - drug effects Cholesterol - blood Cholesterol, HDL - blood Cohort Studies Coronary Artery Disease - epidemiology Coronary Artery Disease - etiology Coronary Artery Disease - prevention & control Drug Utilization Dyslipidemias - blood Dyslipidemias - complications Dyslipidemias - drug therapy Dyslipidemias - epidemiology Health Behavior Humans Hypertension - complications Hypertension - drug therapy Hypertension - epidemiology Hypertension - physiopathology Hypolipidemic Agents - therapeutic use Linear Models Male Middle Aged Risk Assessment Risk Factors Time Factors Treatment Outcome United Kingdom - epidemiology |
| title | Assessing the impact of medication use on trends in major coronary risk factors in older British men: a cohort study |
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