Tolerability of transcranial direct current stimulation in childhood-onset schizophrenia

Background In recent years, transcranial direct current stimulation (tDCS) has been used to study and treat many neuropsychiatric conditions. However, information regarding its tolerability in the pediatric population is lacking. Objective This study aims to investigate the tolerability aspects of t...

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Bibliographic Details
Published in:Brain stimulation 2011-10, Vol.4 (4), p.275-280
Main Authors: Mattai, Anand, Miller, Rachel, Weisinger, Brian, Greenstein, Deanna, Bakalar, Jennifer, Tossell, Julia, David, Christopher, Wassermann, Eric M, Rapoport, Judith, Gogtay, Nitin
Format: Article
Language:English
Subjects:
Adolescent
Child
childhood-onset schizophrenia
dorsolateral prefrontal cortex
Electric Stimulation Therapy
Female
Follow-Up Studies
Humans
Magnetic Resonance Imaging
Male
Neurology
Neuropsychological Tests
Prefrontal Cortex - physiology
Psychiatric Status Rating Scales
Schizophrenia, Childhood - therapy
transcranial direct current stimulation
Transcranial Magnetic Stimulation
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Summary:Background In recent years, transcranial direct current stimulation (tDCS) has been used to study and treat many neuropsychiatric conditions. However, information regarding its tolerability in the pediatric population is lacking. Objective This study aims to investigate the tolerability aspects of tDCS in the childhood-onset schizophrenia (COS) population. Methods Twelve participants with COS completed this inpatient study. Participants were assigned to one of two groups: bilateral anodal dorsolateral prefrontal cortex (DLPFC) stimulation (n = 8) or bilateral cathodal superior temporal gyrus (STG) stimulation (n = 5). Patients received either 2 mA of active treatment or sham treatment (with possibility of open active treatment) for 20 minutes, for a total of 10 sessions (2 weeks). Results tDCS was well tolerated in the COS population with no serious adverse events occurring during the study. Conclusions This is the first study to demonstrate that a 20-minute duration of 2 mA of bilateral anodal and bilateral cathodal DC polarization to the DLPFC and STG was well tolerated in a pediatric population.
ISSN:1935-861X
1876-4754
DOI:10.1016/j.brs.2011.01.001