Genetic Variants and Blood Pressure in a Population-Based Cohort: The Cardiovascular Risk in Young Finns Study

• Published in: Hypertension (Dallas, Tex. 1979) Tex. 1979), 2011-12, Vol.58 (6), p.1079-1085
• Main Authors: Oikonen, Mervi, Tikkanen, Emmi, Juhola, Jonna, Tuovinen, Tarja, Seppälä, Ilkka, Juonala, Markus, Taittonen, Leena, Mikkilä, Vera, Kähönen, Mika, Ripatti, Samuli, Viikari, Jorma, Lehtimäki, Terho, Havulinna, Aki S, Kee, Frank, Newton-Cheh, Christopher, Peltonen, Leena, Schork, Nicholas J, Murray, Sarah S, Berenson, Gerald S, Chen, Wei, Srinivasan, Sathanur R, Salomaa, Veikko, Raitakari, Olli T
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; Blood Pressure - genetics; Body Mass Index; Cardiology. Vascular system; Child; Child, Preschool; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Cohort Studies; Cross-Sectional Studies; Female; Finland - epidemiology; Follow-Up Studies; Genotype; Humans; Hypertension - epidemiology; Hypertension - genetics; Louisiana - epidemiology; Male; Medical sciences; Middle Aged; Polymorphism, Single Nucleotide; Risk; Smoking - epidemiology; Sodium, Dietary; Young Adult
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/HYPERTENSIONAHA.111.179291

Clinical relevance of a genetic predisposition to elevated blood pressure was quantified during the transition from childhood to adulthood in a population-based Finnish cohort (N=2357). Blood pressure was measured at baseline in 1980 (age 3–18 years) and in follow-ups in 1983, 1986, 2001, and 2007. Thirteen single nucleotide polymorphisms associated with blood pressure were genotyped, and 3 genetic risk scores associated with systolic and diastolic blood pressures and their combination were derived for all of the participants. Effects of the genetic risk score were 0.47 mm Hg for systolic and 0.53 mm Hg for diastolic blood pressures (both P