Myocardial regeneration. Transplanting satellite cells into damaged myocardium

Millions of Americans suffer from chronic heart failure. Despite treatments with heart transplantation, cardiomyoplasty, and artificial assist devices, an ideal therapy is yet to be found. Since 1988, we have studied the transplantation of myogenic stem cells from skeletal muscle into injured myocar...

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Bibliographic Details
Published in:Texas Heart Institute journal 1995, Vol.22 (2), p.119-125
Main Authors: Yoon, P D, Kao, R L, Magovern, G J
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - physiology
Cell Survival - physiology
Cells, Cultured
Dogs
Heart Failure - pathology
Heart Failure - surgery
Heart Transplantation - pathology
Muscle, Skeletal - pathology
Muscle, Skeletal - transplantation
Myocardium - pathology
Regeneration - physiology
Stem Cell Transplantation
Stem Cells - pathology
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Summary:Millions of Americans suffer from chronic heart failure. Despite treatments with heart transplantation, cardiomyoplasty, and artificial assist devices, an ideal therapy is yet to be found. Since 1988, we have studied the transplantation of myogenic stem cells from skeletal muscle into injured myocardium in the hope that these cells would multiply and differentiate, thereby improving the function of the failing heart. We have achieved 2 goals thus far: the 1st was improving the culture technique to obtain high yield and purity of the satellite cells; the 2nd was successfully implanting cultured satellite cells in dog hearts and later identifying them as new myocardium. We share our findings here to encourage more study in this promising area.
ISSN:0730-2347