The impact of magnesium sulfate therapy on angiogenic factors in preeclampsia

Abstract Objective The objective was to evaluate whether intravenous magnesium sulfate (magnesium) alters levels of angiogenic factors in women with preeclampsia. Study design This was a prospective cohort study comparing women with preeclampsia treated with magnesium for seizure prophylaxis to thos...

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Bibliographic Details
Published in:Pregnancy hypertension 2012-01, Vol.2 (1), p.16-21
Main Authors: Vadnais, Mary A, Rana, Sarosh, Quant, Hayley S, Salahuddin, Saira, Dodge, Laura E, Lim, Kee-Hak, Ananth Karumanchi, S, Hacker, Michele R
Format: Article
Language:English
Subjects:
Angiogenic factors
Cardiovascular
Magnesium sulfate
Obstetrics and Gynecology
Preeclampsia
Pregnancy
Toxemia
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Summary:Abstract Objective The objective was to evaluate whether intravenous magnesium sulfate (magnesium) alters levels of angiogenic factors in women with preeclampsia. Study design This was a prospective cohort study comparing women with preeclampsia treated with magnesium for seizure prophylaxis to those who were not. Serum levels of angiogenic factors, soluble fms-like tyrosine kinase 1, soluble endoglin and placental growth factor, were measured at the time of diagnosis and approximately 24 h later. Secondary analysis compared women receiving magnesium for preeclampsia to women receiving magnesium for preterm labor. Analysis of covariance was used to compare levels at 24 h, adjusting for levels at enrollment and potential confounders. Results Angiogenic factor levels did not differ between preeclampsia groups with and without magnesium or between preeclampsia and preterm labor groups treated with magnesium (all P > 0.05). Conclusion Magnesium likely decreases seizure risk in preeclampsia by a mechanism other than altering angiogenic factor levels.
ISSN:2210-7789
2210-7797
DOI:10.1016/j.preghy.2011.08.118