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The anabolic response to resistance exercise and a protein-rich meal is not diminished by age
Objectives The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to d...
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| Published in: | The Journal of nutrition, health & aging health & aging, 2011-05, Vol.15 (5), p.376-381 |
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| container_end_page | 381 |
| container_issue | 5 |
| container_start_page | 376 |
| container_title | The Journal of nutrition, health & aging |
| container_volume | 15 |
| creator | Symonsi, T. B. Sheffield-Moore, M. Mamerow, M. M. Wolfe, R. R. Paddon-Jones, Douglas |
| description | Objectives
The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age.
Setting
The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas.
Participants
Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults.
Design
Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum).
Measurements
Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol·kg
−1
min
1
) of L- [ring-
13
C
6
] phenylalanine.
Results
Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073+0.008; post: 0.156±0.021 (SE) %/h, p |
| doi_str_mv | 10.1007/s12603-010-0319-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3280506</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>864194126</sourcerecordid><originalsourceid>FETCH-LOGICAL-c498t-27d86551c3aeaec0afeca6d91fd81a5b0cf93a8e88995b6666c3fc66e3d8f7a63</originalsourceid><addsrcrecordid>eNp1kV1rFDEUhoNYbF39Ad5IEKRXU5OZydeNIMWqUPCmXko4kzmzmzKTrMlssf31Zti1tQVzkwPnOe_5eAl5w9kZZ0x9yLyWrKkYZxVruKnunpETriSrWqX18xLXylRKMXVMXuZ8zVgrjJYvyHHNRa25bE_Iz6sNUgjQxdE7mjBvY8hI57jEPs8QHFL8jcn5vIA9BbpNcUYfquTdhk4II_WZhjjT3k8--LzBnna3FNb4ihwNMGZ8ffhX5MfF56vzr9Xl9y_fzj9dVq41eq5q1WspBHcNIKBjMKAD2Rs-9JqD6JgbTAMatTZGdLI81wxOSmx6PSiQzYp83Otud92EvcMwJxjtNvkJ0q2N4O3jTPAbu443tqk1E2wROD0IpPhrh3m2k88OxxECxl22WrbctOXchXz3hLyOuxTKdgUyopbSNAXie8ilmHPC4X4Uzuxind1bZ4t1drHO3pWat__ucF_x16sCvD8AkB2MQyre-PzAtZwrUbqvSL3nckmFNaaHCf_f_Q_CxbNy</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>869526693</pqid></control><display><type>article</type><title>The anabolic response to resistance exercise and a protein-rich meal is not diminished by age</title><source>Springer Link</source><creator>Symonsi, T. B. ; Sheffield-Moore, M. ; Mamerow, M. M. ; Wolfe, R. R. ; Paddon-Jones, Douglas</creator><creatorcontrib>Symonsi, T. B. ; Sheffield-Moore, M. ; Mamerow, M. M. ; Wolfe, R. R. ; Paddon-Jones, Douglas</creatorcontrib><description>Objectives
The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age.
Setting
The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas.
Participants
Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults.
Design
Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum).
Measurements
Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol·kg
−1
min
1
) of L- [ring-
13
C
6
] phenylalanine.
Results
Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073+0.008; post: 0.156±0.021 (SE) %/h, p<0.001] and older adults (pre: 0.075+0.004; post: 0.152+0.017 %/h, p=0.003) following the meal and resistance exercise bout.
Conclusion
Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-010-0319-z</identifier><identifier>PMID: 21528164</identifier><language>eng</language><publisher>Paris: Springer-Verlag</publisher><subject>Adult ; Aged ; Aging ; Aging - physiology ; Biological and medical sciences ; Biopsy ; Dietary Proteins - pharmacology ; Exercise - physiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Geriatrics/Gerontology ; Humans ; Male ; Meat ; Medicine ; Medicine & Public Health ; Muscle Proteins - biosynthesis ; Neurosciences ; Nutrition ; Phenylalanine - metabolism ; Primary Care Medicine ; Quadriceps Muscle - metabolism ; Quadriceps Muscle - physiology ; Quality of Life Research ; Resistance Training ; Response to Exercise and Protein is Not Reduced by Age ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, health & aging, 2011-05, Vol.15 (5), p.376-381</ispartof><rights>Serdi and Springer Verlag France 2011</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Springer Science & Business Media May 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-27d86551c3aeaec0afeca6d91fd81a5b0cf93a8e88995b6666c3fc66e3d8f7a63</citedby><cites>FETCH-LOGICAL-c498t-27d86551c3aeaec0afeca6d91fd81a5b0cf93a8e88995b6666c3fc66e3d8f7a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24117569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21528164$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Symonsi, T. B.</creatorcontrib><creatorcontrib>Sheffield-Moore, M.</creatorcontrib><creatorcontrib>Mamerow, M. M.</creatorcontrib><creatorcontrib>Wolfe, R. R.</creatorcontrib><creatorcontrib>Paddon-Jones, Douglas</creatorcontrib><title>The anabolic response to resistance exercise and a protein-rich meal is not diminished by age</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Objectives
The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age.
Setting
The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas.
Participants
Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults.
Design
Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum).
Measurements
Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol·kg
−1
min
1
) of L- [ring-
13
C
6
] phenylalanine.
Results
Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073+0.008; post: 0.156±0.021 (SE) %/h, p<0.001] and older adults (pre: 0.075+0.004; post: 0.152+0.017 %/h, p=0.003) following the meal and resistance exercise bout.
Conclusion
Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Dietary Proteins - pharmacology</subject><subject>Exercise - physiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Male</subject><subject>Meat</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Muscle Proteins - biosynthesis</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Phenylalanine - metabolism</subject><subject>Primary Care Medicine</subject><subject>Quadriceps Muscle - metabolism</subject><subject>Quadriceps Muscle - physiology</subject><subject>Quality of Life Research</subject><subject>Resistance Training</subject><subject>Response to Exercise and Protein is Not Reduced by Age</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kV1rFDEUhoNYbF39Ad5IEKRXU5OZydeNIMWqUPCmXko4kzmzmzKTrMlssf31Zti1tQVzkwPnOe_5eAl5w9kZZ0x9yLyWrKkYZxVruKnunpETriSrWqX18xLXylRKMXVMXuZ8zVgrjJYvyHHNRa25bE_Iz6sNUgjQxdE7mjBvY8hI57jEPs8QHFL8jcn5vIA9BbpNcUYfquTdhk4II_WZhjjT3k8--LzBnna3FNb4ihwNMGZ8ffhX5MfF56vzr9Xl9y_fzj9dVq41eq5q1WspBHcNIKBjMKAD2Rs-9JqD6JgbTAMatTZGdLI81wxOSmx6PSiQzYp83Otud92EvcMwJxjtNvkJ0q2N4O3jTPAbu443tqk1E2wROD0IpPhrh3m2k88OxxECxl22WrbctOXchXz3hLyOuxTKdgUyopbSNAXie8ilmHPC4X4Uzuxind1bZ4t1drHO3pWat__ucF_x16sCvD8AkB2MQyre-PzAtZwrUbqvSL3nckmFNaaHCf_f_Q_CxbNy</recordid><startdate>20110501</startdate><enddate>20110501</enddate><creator>Symonsi, T. B.</creator><creator>Sheffield-Moore, M.</creator><creator>Mamerow, M. M.</creator><creator>Wolfe, R. R.</creator><creator>Paddon-Jones, Douglas</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20110501</creationdate><title>The anabolic response to resistance exercise and a protein-rich meal is not diminished by age</title><author>Symonsi, T. B. ; Sheffield-Moore, M. ; Mamerow, M. M. ; Wolfe, R. R. ; Paddon-Jones, Douglas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-27d86551c3aeaec0afeca6d91fd81a5b0cf93a8e88995b6666c3fc66e3d8f7a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Dietary Proteins - pharmacology</topic><topic>Exercise - physiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Male</topic><topic>Meat</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Muscle Proteins - biosynthesis</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Phenylalanine - metabolism</topic><topic>Primary Care Medicine</topic><topic>Quadriceps Muscle - metabolism</topic><topic>Quadriceps Muscle - physiology</topic><topic>Quality of Life Research</topic><topic>Resistance Training</topic><topic>Response to Exercise and Protein is Not Reduced by Age</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Symonsi, T. B.</creatorcontrib><creatorcontrib>Sheffield-Moore, M.</creatorcontrib><creatorcontrib>Mamerow, M. M.</creatorcontrib><creatorcontrib>Wolfe, R. R.</creatorcontrib><creatorcontrib>Paddon-Jones, Douglas</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Symonsi, T. B.</au><au>Sheffield-Moore, M.</au><au>Mamerow, M. M.</au><au>Wolfe, R. R.</au><au>Paddon-Jones, Douglas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The anabolic response to resistance exercise and a protein-rich meal is not diminished by age</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2011-05-01</date><risdate>2011</risdate><volume>15</volume><issue>5</issue><spage>376</spage><epage>381</epage><pages>376-381</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Objectives
The synergistic effect of resistance exercise and protein ingestion on muscle protein anabolism in young adults has been well described. However, it is unclear if this relationship is maintained in older adults who are at greater risk of sarcopenic muscle loss. To this end, we sought to determine if the synergistic response to a bout of resistance exercise and a protein-rich lean beef meal was altered by age.
Setting
The University of Texas Medical Branch, Clinical Research Center, Galveston, Texas.
Participants
Healthy young (n=7, 29±3 y) and older (n=7, 67±2 y) adults.
Design
Mixed muscle fractional synthesis rate (FSR) was calculated during a 3 h post-absorptive/rest period and again during a 5 h period following ingestion of a protein-rich meal (340 g lean beef) and bout of resistance exercise (6 sets of 8 repetitions of isotonic knee extension exercise at 80% one repetition maximum).
Measurements
Venous blood samples and vastus lateralis muscle biopsy samples were obtained during a primed (2.0 µmol/kg) constant infusion (0.08 µmol·kg
−1
min
1
) of L- [ring-
13
C
6
] phenylalanine.
Results
Mixed muscle FSR increased by approximately 108% in both young [pre: 0.073+0.008; post: 0.156±0.021 (SE) %/h, p<0.001] and older adults (pre: 0.075+0.004; post: 0.152+0.017 %/h, p=0.003) following the meal and resistance exercise bout.
Conclusion
Aging does not diminish the increase in muscle protein synthesis following a high-quality protein rich meal and bout of resistance exercise.</abstract><cop>Paris</cop><pub>Springer-Verlag</pub><pmid>21528164</pmid><doi>10.1007/s12603-010-0319-z</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2011-05, Vol.15 (5), p.376-381 |
| issn | 1279-7707 1760-4788 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3280506 |
| source | Springer Link |
| subjects | Adult Aged Aging Aging - physiology Biological and medical sciences Biopsy Dietary Proteins - pharmacology Exercise - physiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Geriatrics/Gerontology Humans Male Meat Medicine Medicine & Public Health Muscle Proteins - biosynthesis Neurosciences Nutrition Phenylalanine - metabolism Primary Care Medicine Quadriceps Muscle - metabolism Quadriceps Muscle - physiology Quality of Life Research Resistance Training Response to Exercise and Protein is Not Reduced by Age Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | The anabolic response to resistance exercise and a protein-rich meal is not diminished by age |
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