The Ph1 Locus Suppresses Cdk2-Type Activity during Premeiosis and Meiosis in Wheat

Despite possessing multiple sets of related (homoeologous) chromosomes, hexaploid wheat (Triticum aestivum) restricts pairing to just true homologs at meiosis. Deletion of a single major locus, Pairing homoeologous1 (Ph1), allows pairing of homoeologs. How can the same chromosomes be processed as ho...

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Bibliographic Details
Published in:The Plant cell 2012-01, Vol.24 (1), p.152-162
Main Authors: Greer, Emma, Martín, Azahara C., Pendle, Ali, Colas, Isabelle, Jones, Alexandra M.E., Moore, Graham, Shaw, Peter
Format: Article
Language:English
Subjects:
Centromeres
Chromatin
Chromosomes
Cyclin-dependent kinase 2
Cyclin-Dependent Kinase 2 - genetics
Cyclin-Dependent Kinase 2 - metabolism
Gene deletion
Gene Expression Regulation, Plant - genetics
Gene Expression Regulation, Plant - physiology
Genetic loci
Heterochromatin
Histone H1
Histones
Meiosis
Meiosis - genetics
Meiosis - physiology
Molecular Sequence Data
Phosphorylation
Plant Proteins - genetics
Plant Proteins - metabolism
Replication
Rye
Telomeres
Triticum - genetics
Triticum - metabolism
Triticum aestivum
Wheat
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Summary:Despite possessing multiple sets of related (homoeologous) chromosomes, hexaploid wheat (Triticum aestivum) restricts pairing to just true homologs at meiosis. Deletion of a single major locus, Pairing homoeologous1 (Ph1), allows pairing of homoeologs. How can the same chromosomes be processed as homologs instead of being treated as nonhomologs? Ph1 was recently defined to a cluster of defective cyclin-dependent kinase (Cdk)-like genes showing some similarity to mammalian Cdk2. We reasoned that the cluster might suppress Cdk2-type activity and therefore affect replication and histone H1 phosphorylation. Our study does indeed reveal such effects, suggesting that Cdk2-type phosphorylation has a major role in determining chromosome specificity during meiosis.
ISSN:1040-4651
1532-298X
DOI:10.1105/tpc.111.094771