Age- and stroke-related skeletal muscle changes: a review for the geriatric clinician

Independently, aging and stroke each have a significant negative impact on skeletal muscle, but the potential cumulative effects of aging and stroke have not been explored. Optimal interventions for individuals post stroke may include those that specifically target skeletal muscle. Addressing change...

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Bibliographic Details
Published in:Journal of geriatric physical therapy (2001) 2012-07, Vol.35 (3), p.155-161
Main Authors: Sions, Jaclyn Megan, Tyrell, Christine M, Knarr, Brian A, Jancosko, Angela, Binder-Macleod, Stuart A
Format: Article
Language:English
Subjects:
Activities of Daily Living
Age Factors
Aging
Aging - physiology
Confidence intervals
Fitness equipment
Geriatrics
Humans
Muscle, Skeletal - metabolism
Muscle, Skeletal - physiopathology
Muscular Atrophy - physiopathology
Muscular system
Musculoskeletal system
Older people
Proteins
Rehabilitation
Stroke
Stroke - physiopathology
Stroke Rehabilitation
Walking
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Description
Summary:Independently, aging and stroke each have a significant negative impact on skeletal muscle, but the potential cumulative effects of aging and stroke have not been explored. Optimal interventions for individuals post stroke may include those that specifically target skeletal muscle. Addressing changes in muscles may minimize activity limitations and enhance participation post stroke. This article reviews the impact of aging and stroke on muscle morphology and composition, including fiber atrophy, reductions in muscle cross-sectional area, changes in muscle fiber distributions, and increases in intramuscular fat. Relationships between changes in muscle structure, muscle function, and physical mobility are reviewed. Clinical recommendations that preserve and enhance skeletal muscle in the aging adult and individuals post stroke are discussed. Future research directions that include systematic comparison of the differences in skeletal muscle between younger and older adults who have sustained a stroke are suggested.
ISSN:1539-8412
2152-0895
2152-0895
1539-8412
DOI:10.1519/JPT.0b013e318236db92