The challenge of developing green tea polyphenols as therapeutic agents

. The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the other hand, there are a number of issues, such as stability, bioavailability and metabolic...

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Bibliographic Details
Published in:Inflammopharmacology 2008-10, Vol.16 (5), p.248-252
Main Authors: Huo, C., Wan, S. B., Lam, W. H., Li, L., Wang, Z., Landis-Piwowar, K. R., Chen, D., Dou, Q. P., Chan, T. H.
Format: Article
Language:English
Subjects:
Allergology
Biological Availability
Biomedical and Life Sciences
Biomedicine
Biotransformation
Catechin - analogs & derivatives
Catechin - chemical synthesis
Catechin - isolation & purification
Catechin - pharmacokinetics
Catechin - therapeutic use
Dermatology
Gastroenterology
Humans
Immunology
Pharmacology/Toxicology
Reiview
Rheumatology
Structure-Activity Relationship
Tea - chemistry
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Summary:. The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the other hand, there are a number of issues, such as stability, bioavailability and metabolic transformations under physiological conditions, facing the development of green tea polyphenols into therapeutic agents. We previously reported that the synthetic peracetate of (-)-EGCG has improved stability and better bioavailability than (-)-EGCG itself and can act as pro-drug under both in vitro and in vivo conditions. Analogs of catechins have been synthesized and their structure activity relationship provides an understanding to the mechanism of proteasome inhibition. Metabolic methylation of catechins leading to methylated (-)-EGCG may alter the biological activities of these compounds.
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-008-8031-x