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The challenge of developing green tea polyphenols as therapeutic agents
. The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the other hand, there are a number of issues, such as stability, bioavailability and metabolic...
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| Published in: | Inflammopharmacology 2008-10, Vol.16 (5), p.248-252 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 252 |
| container_issue | 5 |
| container_start_page | 248 |
| container_title | Inflammopharmacology |
| container_volume | 16 |
| creator | Huo, C. Wan, S. B. Lam, W. H. Li, L. Wang, Z. Landis-Piwowar, K. R. Chen, D. Dou, Q. P. Chan, T. H. |
| description | .
The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the other hand, there are a number of issues, such as stability, bioavailability and metabolic transformations under physiological conditions, facing the development of green tea polyphenols into therapeutic agents. We previously reported that the synthetic peracetate of (-)-EGCG has improved stability and better bioavailability than (-)-EGCG itself and can act as pro-drug under both
in vitro
and
in vivo
conditions. Analogs of catechins have been synthesized and their structure activity relationship provides an understanding to the mechanism of proteasome inhibition. Metabolic methylation of catechins leading to methylated (-)-EGCG may alter the biological activities of these compounds. |
| doi_str_mv | 10.1007/s10787-008-8031-x |
| format | article |
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The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the other hand, there are a number of issues, such as stability, bioavailability and metabolic transformations under physiological conditions, facing the development of green tea polyphenols into therapeutic agents. We previously reported that the synthetic peracetate of (-)-EGCG has improved stability and better bioavailability than (-)-EGCG itself and can act as pro-drug under both
in vitro
and
in vivo
conditions. Analogs of catechins have been synthesized and their structure activity relationship provides an understanding to the mechanism of proteasome inhibition. Metabolic methylation of catechins leading to methylated (-)-EGCG may alter the biological activities of these compounds.</description><identifier>ISSN: 0925-4692</identifier><identifier>EISSN: 1568-5608</identifier><identifier>DOI: 10.1007/s10787-008-8031-x</identifier><identifier>PMID: 18815735</identifier><language>eng</language><publisher>Basel: SP Birkhäuser Verlag Basel</publisher><subject>Allergology ; Biological Availability ; Biomedical and Life Sciences ; Biomedicine ; Biotransformation ; Catechin - analogs & derivatives ; Catechin - chemical synthesis ; Catechin - isolation & purification ; Catechin - pharmacokinetics ; Catechin - therapeutic use ; Dermatology ; Gastroenterology ; Humans ; Immunology ; Pharmacology/Toxicology ; Reiview ; Rheumatology ; Structure-Activity Relationship ; Tea - chemistry</subject><ispartof>Inflammopharmacology, 2008-10, Vol.16 (5), p.248-252</ispartof><rights>Springer 2008</rights><rights>Birkhäuser Verlag, Basel, 2008 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387x-f0f0a876d28fe1f07c58b23c801761b048fa831220bd763838f7d249c4d905143</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18815735$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huo, C.</creatorcontrib><creatorcontrib>Wan, S. B.</creatorcontrib><creatorcontrib>Lam, W. H.</creatorcontrib><creatorcontrib>Li, L.</creatorcontrib><creatorcontrib>Wang, Z.</creatorcontrib><creatorcontrib>Landis-Piwowar, K. R.</creatorcontrib><creatorcontrib>Chen, D.</creatorcontrib><creatorcontrib>Dou, Q. P.</creatorcontrib><creatorcontrib>Chan, T. H.</creatorcontrib><title>The challenge of developing green tea polyphenols as therapeutic agents</title><title>Inflammopharmacology</title><addtitle>Inflammopharmacol</addtitle><addtitle>Inflammopharmacology</addtitle><description>.
The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the other hand, there are a number of issues, such as stability, bioavailability and metabolic transformations under physiological conditions, facing the development of green tea polyphenols into therapeutic agents. We previously reported that the synthetic peracetate of (-)-EGCG has improved stability and better bioavailability than (-)-EGCG itself and can act as pro-drug under both
in vitro
and
in vivo
conditions. Analogs of catechins have been synthesized and their structure activity relationship provides an understanding to the mechanism of proteasome inhibition. Metabolic methylation of catechins leading to methylated (-)-EGCG may alter the biological activities of these compounds.</description><subject>Allergology</subject><subject>Biological Availability</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Biotransformation</subject><subject>Catechin - analogs & derivatives</subject><subject>Catechin - chemical synthesis</subject><subject>Catechin - isolation & purification</subject><subject>Catechin - pharmacokinetics</subject><subject>Catechin - therapeutic use</subject><subject>Dermatology</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Immunology</subject><subject>Pharmacology/Toxicology</subject><subject>Reiview</subject><subject>Rheumatology</subject><subject>Structure-Activity Relationship</subject><subject>Tea - chemistry</subject><issn>0925-4692</issn><issn>1568-5608</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kU1v1DAQhi0Eosu2P4ALyglOoWM7sScXJFSVglSpl3K2vMk4SeWNg51U23-Pq13xcelpDvPMO2M_jL3n8JkD6MvEQaMuAbBEkLw8vGIbXissawX4mm2gEXVZqUacsXcpPQCA0qp5y844Iq-1rDfs5n6goh2s9zT1VARXdPRIPszj1Bd9JJqKhWwxB_80DzQFnwqbimWgaGdal7EtbE_Tks7ZG2d9ootT3bKf367vr76Xt3c3P66-3patRH0oHTiwqFUn0BF3oNsad0K2CFwrvoMKnUXJhYBdp5VEiU53omraqmug5pXcsi_H3Hnd7alr8-5ovZnjuLfxyQQ7mv870ziYPjwaKUEp0Dng0ykghl8rpcXsx9SS93aisCbTgJAam7x6yz6-SKqmEYgCMsiPYBtDSpHcn3M4mGdR5ijKZFHmWZQ55JkP_77j78TJTAbEEUi5ldVE8xDWOOW_fSH1N_rMn0s</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Huo, C.</creator><creator>Wan, S. 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H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387x-f0f0a876d28fe1f07c58b23c801761b048fa831220bd763838f7d249c4d905143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Allergology</topic><topic>Biological Availability</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Biotransformation</topic><topic>Catechin - analogs & derivatives</topic><topic>Catechin - chemical synthesis</topic><topic>Catechin - isolation & purification</topic><topic>Catechin - pharmacokinetics</topic><topic>Catechin - therapeutic use</topic><topic>Dermatology</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Immunology</topic><topic>Pharmacology/Toxicology</topic><topic>Reiview</topic><topic>Rheumatology</topic><topic>Structure-Activity Relationship</topic><topic>Tea - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huo, C.</creatorcontrib><creatorcontrib>Wan, S. B.</creatorcontrib><creatorcontrib>Lam, W. H.</creatorcontrib><creatorcontrib>Li, L.</creatorcontrib><creatorcontrib>Wang, Z.</creatorcontrib><creatorcontrib>Landis-Piwowar, K. R.</creatorcontrib><creatorcontrib>Chen, D.</creatorcontrib><creatorcontrib>Dou, Q. P.</creatorcontrib><creatorcontrib>Chan, T. H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Inflammopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huo, C.</au><au>Wan, S. B.</au><au>Lam, W. H.</au><au>Li, L.</au><au>Wang, Z.</au><au>Landis-Piwowar, K. R.</au><au>Chen, D.</au><au>Dou, Q. P.</au><au>Chan, T. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The challenge of developing green tea polyphenols as therapeutic agents</atitle><jtitle>Inflammopharmacology</jtitle><stitle>Inflammopharmacol</stitle><addtitle>Inflammopharmacology</addtitle><date>2008-10</date><risdate>2008</risdate><volume>16</volume><issue>5</issue><spage>248</spage><epage>252</epage><pages>248-252</pages><issn>0925-4692</issn><eissn>1568-5608</eissn><abstract>.
The health benefits of green tea and its main constituent (-)-epigallocatechin gallate [(-)-EGCG] have been widely supported by results from epidemiological, cell culture, animal and clinical studies. On the other hand, there are a number of issues, such as stability, bioavailability and metabolic transformations under physiological conditions, facing the development of green tea polyphenols into therapeutic agents. We previously reported that the synthetic peracetate of (-)-EGCG has improved stability and better bioavailability than (-)-EGCG itself and can act as pro-drug under both
in vitro
and
in vivo
conditions. Analogs of catechins have been synthesized and their structure activity relationship provides an understanding to the mechanism of proteasome inhibition. Metabolic methylation of catechins leading to methylated (-)-EGCG may alter the biological activities of these compounds.</abstract><cop>Basel</cop><pub>SP Birkhäuser Verlag Basel</pub><pmid>18815735</pmid><doi>10.1007/s10787-008-8031-x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Inflammopharmacology, 2008-10, Vol.16 (5), p.248-252 |
| issn | 0925-4692 1568-5608 |
| language | eng |
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| source | Springer Link |
| subjects | Allergology Biological Availability Biomedical and Life Sciences Biomedicine Biotransformation Catechin - analogs & derivatives Catechin - chemical synthesis Catechin - isolation & purification Catechin - pharmacokinetics Catechin - therapeutic use Dermatology Gastroenterology Humans Immunology Pharmacology/Toxicology Reiview Rheumatology Structure-Activity Relationship Tea - chemistry |
| title | The challenge of developing green tea polyphenols as therapeutic agents |
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