Development and validation of simultaneous spectrophotometric methods for drotaverine hydrochloride and aceclofenac from tablet dosage form

Two simple spectrophotometric methods have been developed for simultaneous estimation of drotaverine hydrochloride and aceclofenac from tablet dosage form. Method I is a simultaneous equation method (Vierodt's method), wavelengths selected are 306.5 and 276 nm. Method II is the absorbance ratio...

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Bibliographic Details
Published in:Indian journal of pharmaceutical sciences 2011-05, Vol.73 (3), p.296-300
Main Authors: Shah, S A, Shah, D R, Chauhan, R S, Jain, J R
Format: Article
Language:English
Subjects:
Analytical chemistry
Anti-inflammatory drugs
Antispasmodics
Calibration
Chemical properties
Drug dosages
Identification and classification
Methods
Pharmaceutical chemistry
Short Communication
Spectrophotometry
Studies
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Summary:Two simple spectrophotometric methods have been developed for simultaneous estimation of drotaverine hydrochloride and aceclofenac from tablet dosage form. Method I is a simultaneous equation method (Vierodt's method), wavelengths selected are 306.5 and 276 nm. Method II is the absorbance ratio method (Q-Analysis), which employs 298.5 nm as λ(1) and 276 nm as λ(2) (λmax of AF) for formation of equations. Both the methods were found to be linear between the range of 8-32 μg/ml for drotaverine and 10-40 μg/ml for aceclofenac. The accuracy and precision were determined and found to comply with ICH guidelines. Both the methods showed good reproducibility and recovery with % RSD in the desired range. The methods were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of drotaverine and aceclofenac in their combined tablet dosage form.
ISSN:0250-474X
1998-3743
DOI:10.4103/0250-474X.93520