Dietary Calcium and Serum 25‐Hydroxyvitamin D Status in Relation to BMD Among U.S. Adults

• Published in: Journal of bone and mineral research 2009-05, Vol.24 (5), p.935-942
• Main Authors: Bischoff‐Ferrari, Heike A, Kiel, Douglas P, Dawson‐Hughes, Bess, Orav, John E, Li, Ruifeng, Spiegelman, Donna, Dietrich, Thomas, Willett, Walter C
• Format: Article
• Language: English
• Subjects: 25‐hydroxyvitamin D; Adult; adults; Aged; Aged, 80 and over; Biological and medical sciences; BMD; Bone Density - physiology; Calcium, Dietary - administration & dosage; Diet - statistics & numerical data; dietary calcium intake; Female; Fundamental and applied biological sciences. Psychology; Hip - physiology; Humans; Male; men and women; Middle Aged; Skeleton and joints; United States; Vertebrates: osteoarticular system, musculoskeletal system; Vitamin D - analogs & derivatives; Vitamin D - blood
• ISSN: 0884-0431; 1523-4681
• DOI: 10.1359/jbmr.081242

A higher calcium intake is still the primary recommendation for the prevention of osteoporosis, whereas vitamin D deficiency is often not addressed. To study the relative importance of dietary calcium intake and serum 25‐hydroxyvitamin D [25(OH)D] status in regard to hip BMD, 4958 community‐dwelling women and 5003 men ≥20 yr of age from the U.S. NHANES III population‐based survey were studied. Calcium supplement users and individuals with a prior radius or hip fracture were excluded. We calculated standardized means for BMD by quartiles of sex‐specific calcium intake for three 25(OH)D categories (50 nM. Among men, there was no significant association between a higher calcium intake beyond the upper end of the lowest quartile (626 mg/d) and BMD within all 25(OH)D categories. Among both sexes, BMD increased stepwise and significantly with higher 25(OH)D concentrations (