Magnesium intake, plasma C-peptide, and colorectal cancer incidence in US women: a 28-year follow-up study

• Published in: British journal of cancer 2012-03, Vol.106 (7), p.1335-1341
• Main Authors: Zhang, X, Giovannucci, E L, Wu, K, Smith-Warner, S A, Fuchs, C S, Pollak, M, Willett, W C, Ma, J
• Format: Article
• Language: English
• Subjects: 692/699/317; 692/699/67/1504/1885; 692/700/459/1994; 692/700/478/174; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Body Mass Index; C-Peptide - blood; Calcium; Cancer; Cancer Research; Carcinogenesis; Colorectal cancer; colorectal carcinoma; Colorectal Neoplasms - epidemiology; Diabetes; Diet; Diets; Drug Resistance; Epidemiology; Female; Females; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Incidence; Insulin - metabolism; Insulin resistance; Insulin Secretion; Magnesium; Medical personnel; Medical research; Medical sciences; Middle Aged; Molecular Medicine; Nurses; Nursing; Oncology; Peptides; Plasma; Prospective Studies; Public health; Questionnaires; Risk Factors; Skin cancer; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Tumors; United States - epidemiology; Womens health
• ISSN: 0007-0920; 1532-1827
• DOI: 10.1038/bjc.2012.76

Background: Laboratory studies suggest a possible role of magnesium intake in colorectal carcinogenesis but epidemiological evidence is inconclusive. Method: We tested magnesium–colorectal cancer hypothesis in the Nurses’ Health Study, in which 85 924 women free of cancer in 1980 were followed until June 2008. Cox proportional hazards regression models were used to estimate multivariable relative risks (MV RRs, 95% confidence intervals). Results: In the age-adjusted model, magnesium intake was significantly inversely associated with colorectal cancer risk; the RRs from lowest to highest decile of total magnesium intake were 1.0 (ref), 0.93, 0.81, 0.72, 0.74, 0.77, 0.72, 0.75, 0.80, and 0.67 ( P trend