Verbal Serial List Learning in Mild Cognitive Impairment: A Profile Analysis of Interference, Forgetting, and Errors

Using cluster analysis Libon et al. (2010) found three verbal serial list-learning profiles involving delay memory test performance in patients with mild cognitive impairment (MCI). Amnesic MCI (aMCI) patients presented with low scores on delay free recall and recognition tests; mixed MCI (mxMCI) pa...

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Bibliographic Details
Published in:Journal of the International Neuropsychological Society 2011-09, Vol.17 (5), p.905-914
Main Authors: Libon, David J., Bondi, Mark W., Price, Catherine C., Lamar, Melissa, Eppig, Joel, Wambach, Denene M., Nieves, Christine, Delano-Wood, Lisa, Giovannetti, Tania, Lippa, Carol, Kabasakalian, Anahid, Cosentino, Stephanie, Swenson, Rod, Penney, Dana L.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alzheimer's disease
Analysis of Variance
Attention - physiology
Biomarkers
Cluster analysis
Cognition Disorders - complications
Cognitive ability
Cues
Dementia
Humans
Memory Disorders - diagnosis
Memory Disorders - etiology
Mental Recall - physiology
Mental Status Schedule
Middle Aged
Mortality
Neuropsychological Tests
Older people
Recognition, Psychology
Verbal Learning - physiology
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Summary:Using cluster analysis Libon et al. (2010) found three verbal serial list-learning profiles involving delay memory test performance in patients with mild cognitive impairment (MCI). Amnesic MCI (aMCI) patients presented with low scores on delay free recall and recognition tests; mixed MCI (mxMCI) patients scored higher on recognition compared to delay free recall tests; and dysexecutive MCI (dMCI) patients generated relatively intact scores on both delay test conditions. The aim of the current research was to further characterize memory impairment in MCI by examining forgetting/savings, interference from a competing word list, intrusion errors/perseverations, intrusion word frequency, and recognition foils in these three statistically determined MCI groups compared to normal control (NC) participants. The aMCI patients exhibited little savings, generated more highly prototypic intrusion errors, and displayed indiscriminate responding to delayed recognition foils. The mxMCI patients exhibited higher saving scores, fewer and less prototypic intrusion errors, and selectively endorsed recognition foils from the interference list. dMCI patients also selectively endorsed recognition foils from the interference list but performed similarly compared to NC participants. These data suggest the existence of distinct memory impairments in MCI and caution against the routine use of a single memory test score to operationally define MCI. (JINS, 2011, 17, 905–914)
ISSN:1355-6177
1469-7661
DOI:10.1017/S1355617711000944