Cell Biology of the BLOC-1 Complex Subunit Dysbindin, a Schizophrenia Susceptibility Gene

• Published in: Molecular neurobiology 2011-08, Vol.44 (1), p.53-64
• Main Authors: Mullin, Ariana P., Gokhale, Avanti, Larimore, Jennifer, Faundez, Victor
• Format: Article
• Language: English
• Subjects: Animals; Biology; Biomedical and Life Sciences; Biomedicine; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cell Biology; Disease; Gene loci; Genetic Predisposition to Disease; Genomes; Humans; Mutation; Nerve Tissue Proteins - metabolism; Neurobiology; Neurology; Neurosciences; Pathogenesis; Patients; Protein Subunits - metabolism; Proteins; Schizophrenia; Schizophrenia - genetics
• ISSN: 0893-7648; 1559-1182; 1559-1182
• DOI: 10.1007/s12035-011-8183-3

There is growing interest in the biology of dysbindin and its genetic locus ( DTNBP1 ) due to genetic variants associated with an increased risk of schizophrenia. Reduced levels of dysbindin mRNA and protein in the hippocampal formation of schizophrenia patients further support involvement of this locus in disease risk. Here, we discuss phylogenetically conserved dysbindin molecular interactions that define its contribution to the assembly of the biogenesis of lysosome-related organelles complex-1 (BLOC-1). We explore fundamental cellular processes where dysbindin and the dysbindin-containing BLOC-1 complex are implicated. We propose that cellular, tissue, and system neurological phenotypes from dysbindin deficiencies in model genetic organisms, and likely individuals affected with schizophrenia, emerge from abnormalities in few core cellular mechanisms controlled by BLOC-1-dysbindin-containing complex rather than from defects in dysbindin itself.