Attractive guidance: How the chemokine SDF1/CXCL12 guides different cells to different locations

► Review of SDF1-guided cell migration. ► Discussion of the control of SDF1 through microRNAs and CXCR7. ► New model for dispersion of cells across a uniform SDF1 expression domain. During the development and adult life of multicellular organisms cells move from one location to another as they assem...

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Bibliographic Details
Published in:Seminars in cell & developmental biology 2012-05, Vol.23 (3), p.333-340
Main Authors: Lewellis, Stephen W., Knaut, Holger
Format: Article
Language:English
Subjects:
Animals
Cajal-Retzius cells
Cell Movement
Chemokine CXCL12 - genetics
Chemokine CXCL12 - metabolism
CXCR4
CXCR7
Germ cells
Humans
Interneurons
MicroRNAs - genetics
SDF1/CXCL12
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Summary:► Review of SDF1-guided cell migration. ► Discussion of the control of SDF1 through microRNAs and CXCR7. ► New model for dispersion of cells across a uniform SDF1 expression domain. During the development and adult life of multicellular organisms cells move from one location to another as they assemble into organs, seal a wound or fight pathogens. For navigation, migrating cells follow cues that guide them to their final position. Frequently, a single cue simultaneously guides different cells to different positions. Recent studies of one such cue—the chemokine SDF1—suggest strategies for how the animal achieves this task without causing erroneous migration.
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2012.03.009