Pt-Catalyzed Pentannulations from In Situ Generated Metallo−Carbenoids Utilizing Propargylic Esters

A highly selective and efficient Pt-catalyzed pentannulation reaction beginning from propargylic esters is described. The key to this reaction is the use of a PtCl2(PPh3)2/PhIO catalyst combination that allows the in situ generation of Pt−carbenoid intermediates, which lead to good yields (61−84%) o...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2005-09, Vol.127 (36), p.12468-12469
Main Authors: Bhanu Prasad, B. A, Yoshimoto, Francis K, Sarpong, Richmond
Format: Article
Language:English
Subjects:
Alkynes - chemistry
Catalysis
Chemistry
Cyclization
Esters - chemical synthesis
Esters - chemistry
Exact sciences and technology
Kinetics and mechanisms
Molecular Structure
Organic chemistry
Organoplatinum Compounds - chemistry
Platinum - chemistry
Reactivity and mechanisms
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Summary:A highly selective and efficient Pt-catalyzed pentannulation reaction beginning from propargylic esters is described. The key to this reaction is the use of a PtCl2(PPh3)2/PhIO catalyst combination that allows the in situ generation of Pt−carbenoid intermediates, which lead to good yields (61−84%) of the desired pentannulated compounds.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja053192c