Pharmacokinetics of linagliptin in subjects with hepatic impairment

• Published in: British journal of clinical pharmacology 2012-07, Vol.74 (1), p.75-85
• Main Authors: Graefe‐Mody, Ulrike, Rose, Peter, Retlich, Silke, Ring, Arne, Waldhauser, Lisa, Cinca, Rodica, Woerle, Hans‐Juergen
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Diabetes Mellitus, Type 2 - drug therapy; Diabetes. Impaired glucose tolerance; Dipeptidyl-Peptidase IV Inhibitors - administration & dosage; Dipeptidyl-Peptidase IV Inhibitors - pharmacokinetics; Dose-Response Relationship, Drug; DPP‐4 inhibitor; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Gastroenterology. Liver. Pancreas. Abdomen; hepatic impairment; Humans; Linagliptin; Liver Diseases - metabolism; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Other diseases. Semiology; Pharmacokinetics; Pharmacology. Drug treatments; Purines - administration & dosage; Purines - pharmacokinetics; Quinazolines - administration & dosage; Quinazolines - pharmacokinetics; Severity of Illness Index; type 2 diabetes mellitus
• ISSN: 0306-5251; 1365-2125
• DOI: 10.1111/j.1365-2125.2012.04173.x

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Linagliptin is an oral, highly selective dipeptidyl peptidase‐4 (DPP‐4) inhibitor that was approved in the United States, Europe and elsewhere in 2011 for the treatment of type 2 diabetes mellitus. • The elimination of linagliptin is primarily non‐renal. Therefore, a potential effect of hepatic impairment on the elimination of linagliptin may have important implications for dosing recommendations. WHAT THIS STUDY ADDS • This study shows that mild, moderate or severe hepatic impairment did not result in an increase in linagliptin exposure after single and multiple dosing as compared with normal hepatic function. • No linagliptin dose adjustment is required in patients with any degree of hepatic impairment. AIM To investigate whether hepatic impairment affects linagliptin pharmacokinetics, pharmacodynamics and tolerability. METHOD This open label, parallel group, single centre study enrolled patients with mild (n= 8), moderate (n= 9) or severe (n= 8) hepatic impairment and healthy subjects (n= 8). Groups were matched with regard to age, weight and gender. Primary endpoints were linagliptin exposure following 5 mg linagliptin once daily for 7 days in patients with mild and moderate hepatic impairment vs. healthy subjects or after a single 5 mg dose for patients with severe hepatic impairment vs. healthy subjects. RESULTS In mild hepatic impairment, steady‐state linagliptin exposure was slightly lower than in healthy subjects [AUCτ,ss geometric mean ratio (GMR) 75.5%, 90% confidence interval (CI) 61.6%, 92.5%, and Cmax,ss GMR 64.4%, 90% CI 43.2%, 96.0%]. Exposure also tended to be lower in moderate hepatic impairment (AUCτ,ss GMR 85.5%, 90% CI 70.2%, 104.2% and Cmax,ss GMR 92.3%, 90% CI 62.8%, 135.6%). After a single dose, AUC(0,24 h) in patients with severe hepatic impairment was similar to that in healthy subjects (GMR 100.4%, 90% CI 75.0%, 134.3%) and Cmax was lower (GMR 77.0%, 90% CI 44.9%, 132.3%). Accumulation based on AUC or Cmax and renal excretion of unchanged linagliptin (≤7%) were comparable across groups. Median plasma DPP‐4 inhibition was similar in healthy subjects (91%), and patients with mild (90%) and moderate (89%) hepatic impairment at steady‐state trough concentrations, and in patients with severe hepatic impairment 24 h after a single dose (84%). Linagliptin was well tolerated. CONCLUSION Mild, moderate or severe hepatic impairment did not result in an increase in linagliptin exposure after single