Involvement of the atrial natriuretic peptide in cardiovascular pathophysiology and its relationship with exercise

In this minireview we describe the involvement of the atrial natriuretic peptide (ANP) in cardiovascular pathophysiology and exercise. The ANP has a broad homeostatic role and exerts complex effects on the cardio-circulatory hemodynamics, it is produced by the left atrium and has a key role in regul...

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Bibliographic Details
Published in:International archives of medicine 2012-02, Vol.5 (1), p.4-4
Main Authors: de Almeida, Júlio C, Alves, Clodoaldo L, de Abreu, Luiz Carlos, Sato, Monica A, Fonseca, Fernando L, de Mello Monteiro, Carlos B, Vanderlei, Luiz Carlos M, Macedo, Jr, Hugo, Tavares, Carlos M, Herrero, Dafne, Rodrigues, Luciano Mr, Valenti, Vitor E
Format: Article
Language:English
Subjects:
Cardiovascular diseases
Care and treatment
Exercise
Health aspects
Natriuretic peptides
Physiological aspects
Review
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Summary:In this minireview we describe the involvement of the atrial natriuretic peptide (ANP) in cardiovascular pathophysiology and exercise. The ANP has a broad homeostatic role and exerts complex effects on the cardio-circulatory hemodynamics, it is produced by the left atrium and has a key role in regulating sodium and water balance in mammals and humans. The dominant stimulus for its release is atrial wall tension, commonly caused by exercise. The ANP is involved in the process of lipolysis through a cGMP signaling pathway and, as a consequence, reducing blood pressure by decreasing the sensitivity of vascular smooth muscle to the action of vasoconstrictors and regulate fluid balance. The increase of this hormone is associated with better survival in patients with chronic heart failure (CHF). This minireview provides new evidence based on recent studies related to the beneficial effects of exercise in patients with cardiovascular disease, focusing on the ANP.
ISSN:1755-7682
1755-7682
DOI:10.1186/1755-7682-5-4