Evaluation of a Second-Generation Self-Expanding Variable-Porosity Flow Diverter in a Rabbit Elastase Aneurysm Model

• Published in: American journal of neuroradiology : AJNR 2011-09, Vol.32 (8), p.1399-1407
• Main Authors: IONITA, C. N, NATARAJAN, S. K, WANG, W, HOPKINS, L. N, LEVY, E. I, SIDDIQUI, A. H, BEDNAREK, D. R, RUDIN, S
• Format: Article
• Language: English
• Subjects: Animals; Biological and medical sciences; Cardiovascular system; Disease Models, Animal; Equipment Design; Interventional; Intracranial Aneurysm - chemically induced; Intracranial Aneurysm - surgery; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Nervous system; Pancreatic Elastase - administration & dosage; Porosity; Rabbits; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Stents
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.A2548

The self-expanding V-POD is a second-generation flow-diverting device with a low-porosity PTFE patch on a self-expanding microstent. The authors evaluated this device for the treatment of elastase-induced aneurysms in rabbits. Three V-POD types (A, circumferential patch closed-cell stent [n = 9]; B, asymmetric patch closed-cell stent [n = 7]; and C, asymmetric patch open-cell stent [n = 4]) were evaluated by using angiography, conebeam micro-CT, histology, and SEM. Aneurysm flow modifications were expressed in terms of immediate poststent/prestent ratios of maximum CA volume entering the aneurysm dome tracked on procedural angiograms. Flow modifications were correlated with 4 weeks' follow-up angiographic, micro-CT, histologic, and SEM results. Mechanical stent-deployment difficulties in 4 aneurysms (1 type A; 3 type B) led to suboptimal results and exclusion from analysis. Of the remaining 16 aneurysms, 4-week post-treatment angiograms showed no aneurysm filling in 10 (63%), 3 (∼19%) had no filling with a small remnant neck, and 3 (∼19%) had