Childhood body mass index and adult pro-inflammatory and pro-thrombotic risk factors: data from the New Delhi birth cohort

Weight gain and growth in early life may influence adult pro-inflammatory and pro-thrombotic cardiovascular risk factors. Follow-up of a birth cohort in New Delhi, India, whose weight and height were measured every 6 months until age 21 years. Body mass index (BMI) at birth, during infancy (2 years)...

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Bibliographic Details
Published in:International journal of epidemiology 2011-02, Vol.40 (1), p.102-111
Main Authors: LAKSHMY, Ramakrishnan, FALL, Caroline Hd, BHARGAVA, Santosh K, HARSHPAL SINGH SACHDEV, OSMOND, Clive, PRABHAKARAN, Dorairaj, SUSHANT DEY BISWAS, TANDON, Nikhil, RAMJI, Siddharth, KOLLI SRINATH REDDY, BARKER, David J. P
Format: Article
Language:English
Subjects:
Adiposity
Adolescence
Adolescent
Adolescents
Adult
Adults
Age
Biological and medical sciences
Biomarkers - analysis
Body mass
Body Mass Index
body weight
C-Reactive Protein - analysis
Cardiorespiratory
Cardiovascular diseases
Child
Children
Cohort Studies
Female
Fibrinogen - analysis
General aspects
Height
Humans
India - epidemiology
Infants
Inflammation - blood
Inflammation - epidemiology
Male
Medical sciences
Men
Miscellaneous
obesity
Plasminogen Activator Inhibitor 1 - analysis
Proteins
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Surveys and Questionnaires
Thrombosis - blood
Thrombosis - epidemiology
Weight
Women
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Summary:Weight gain and growth in early life may influence adult pro-inflammatory and pro-thrombotic cardiovascular risk factors. Follow-up of a birth cohort in New Delhi, India, whose weight and height were measured every 6 months until age 21 years. Body mass index (BMI) at birth, during infancy (2 years), childhood (11 years) and adulthood (26-32 years) and BMI gain between these ages were analysed in 886 men and 640 women with respect to adult fibrinogen, high-sensitivity C-reactive protein (hsCRP) and plasminogen activator inhibitor-1 (PAI-1) concentrations. All the pro-inflammatory/pro-thrombotic risk factors were higher in participants with higher adiposity. In women, BMI at birth and age 2 years was inversely related to fibrinogen (P = 0.002 and 0.05) and, after adjusting for adult adiposity, to hsCRP (P = 0.02 and 0.009). After adjusting for adult adiposity, BMI at 2 years was inversely related to hsCRP and PAI-1 concentrations (P 
ISSN:0300-5771
1464-3685
DOI:10.1093/ije/dyq121