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Distribution of the modified nucleoside Q and its derivatives in animal and plant transfer RNA's

The modified nucleoside, 7-(4,5-cis-dihydroxy-l-cyclopenten-3-yl-aminomethyl)-7-deazaguanosine, designated as Q, and its derivative, Q*, were found in tRNA's from various organisms, including several mammalian tissues, other animals such as starfish, lingula and hagfish, and wheat germ. Q isola...

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Bibliographic Details
Published in:Nucleic acids research 1975-10, Vol.2 (10), p.1931-1939
Main Authors: Kasai, H, Kuchino, Y, Nihei, K
Format: Article
Language:English
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Summary:The modified nucleoside, 7-(4,5-cis-dihydroxy-l-cyclopenten-3-yl-aminomethyl)-7-deazaguanosine, designated as Q, and its derivative, Q*, were found in tRNA's from various organisms, including several mammalian tissues, other animals such as starfish, lingula and hagfish, and wheat germ. Q isolated from rat liver tRNA was found to be identical with E. coli Q by mass spectrometry and thin-layer chromatography. Thus the rare modified nucleoside Q originally isolated from E. coli tRNA, is widely distributed in various organisms. Analysis of the mass spectrum of Q* suggested that it has a different side chain from Q.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/2.10.1931