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Distribution of the modified nucleoside Q and its derivatives in animal and plant transfer RNA's
The modified nucleoside, 7-(4,5-cis-dihydroxy-l-cyclopenten-3-yl-aminomethyl)-7-deazaguanosine, designated as Q, and its derivative, Q*, were found in tRNA's from various organisms, including several mammalian tissues, other animals such as starfish, lingula and hagfish, and wheat germ. Q isola...
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Published in: | Nucleic acids research 1975-10, Vol.2 (10), p.1931-1939 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | The modified nucleoside, 7-(4,5-cis-dihydroxy-l-cyclopenten-3-yl-aminomethyl)-7-deazaguanosine, designated as Q, and its derivative, Q*, were found in tRNA's from various organisms, including several mammalian tissues, other animals such as starfish, lingula and hagfish, and wheat germ. Q isolated from rat liver tRNA was found to be identical with E. coli Q by mass spectrometry and thin-layer chromatography. Thus the rare modified nucleoside Q originally isolated from E. coli tRNA, is widely distributed in various organisms. Analysis of the mass spectrum of Q* suggested that it has a different side chain from Q. |
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ISSN: | 0305-1048 1362-4962 |
DOI: | 10.1093/nar/2.10.1931 |