A comparative study of Y chromosome microdeletions in infertile males from two Chinese populations

To compare the prevalence and type of Y-microdeletions in Hong Kong and Shanghai men with severe male-factor infertility. Seven Y-linked sequence tagged site (STS) primers and seven gene-specific primers were screened in 293 infertile males (139 from Hong Kong and 154 from Shanghai) and 161 fertile...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2002-08, Vol.19 (8), p.376-383
Main Authors: TSE, J. Y. M, YEUNG, W. S. B, NG, E. H. Y, CHENG, L. N, ZHU, H. B, TENG, X. M, LIU, Y. K, HO, P. C
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
China - epidemiology
Chromosome Deletion
Chromosomes, Human, Y - genetics
DNA - chemistry
DNA - genetics
Follicle Stimulating Hormone - blood
Gynecology. Andrology. Obstetrics
Humans
Infertility, Male - epidemiology
Infertility, Male - genetics
Luteinizing Hormone - blood
Male
Male genital diseases
Medical sciences
Middle Aged
Non tumoral diseases
Oligospermia - epidemiology
Oligospermia - genetics
Polymerase Chain Reaction
Sequence Tagged Sites
Sex Chromosome Aberrations
Testosterone - blood
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Summary:To compare the prevalence and type of Y-microdeletions in Hong Kong and Shanghai men with severe male-factor infertility. Seven Y-linked sequence tagged site (STS) primers and seven gene-specific primers were screened in 293 infertile males (139 from Hong Kong and 154 from Shanghai) and 161 fertile men (61 from Hong Kong and 100 from Shanghai). Serum FSH, LH, and testosterone levels were also measured in these men. The incidence of Yq microdeletions in nonobstructive azoospermic men from Hong Kong (8.5%) and Shanghai (6%) was similar. Yq microdeletions were observed in severe oligospermic patients (8.5%) from Hong Kong but not from Shanghai. Among the 9 Hong Kong men with Y-microdeletions, 8 had AZFc deletion and one had AZFb deletion. In contrast, 6 of 9 men from Shanghai with Y-microdeletions had AZFb deletion. The incidence of AZFb deletion among Y-microdeleted men was statistically different between the two populations. Two of the men with AZFb deletion also had AZFa and AZFc deletions. Regional variations in the type of Y-microdeletion existed between Hong Kong and Shanghai infertile males.
ISSN:1058-0468
1573-7330
DOI:10.1023/A:1016346421177