Reduced striatal dopamine D1–D2 receptor heteromer expression and behavioural subsensitivity in juvenile rats

Highlights ► Dopamine D1 and D2 receptors are coexpressed with dynorphin and enkephalin. ► Striatal coexpression of D1 and D2 receptors is age-dependent. ► Juvenile rats have lower striatal D1–D2 receptor heteromer expression than adults. ► Juvenile rats are subsensitive to D1–D2 receptor heteromer-...

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Bibliographic Details
Published in:Neuroscience 2012-12, Vol.225, p.130-139
Main Authors: Perreault, M.L, Hasbi, A, Alijaniaram, M, O’Dowd, B.F, George, S.R
Format: Article
Language:English
Subjects:
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - analogs & derivatives
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology
Age Factors
Animals
Animals, Newborn
Biological and medical sciences
Cells, Cultured
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Corpus Striatum - cytology
dopamine D1–D2 receptor heteromer
dynorphin
Dynorphins - metabolism
enkephalin
Enkephalins - metabolism
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental - drug effects
Gene Expression Regulation, Developmental - physiology
grooming
Grooming - drug effects
Grooming - physiology
juvenile
Male
Neurology
Neurons - drug effects
Neurons - metabolism
nucleus accumbens
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D1 - metabolism
Receptors, Dopamine D2 - metabolism
Vertebrates: nervous system and sense organs
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Summary:Highlights ► Dopamine D1 and D2 receptors are coexpressed with dynorphin and enkephalin. ► Striatal coexpression of D1 and D2 receptors is age-dependent. ► Juvenile rats have lower striatal D1–D2 receptor heteromer expression than adults. ► Juvenile rats are subsensitive to D1–D2 receptor heteromer-induced grooming.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2012.08.042