Further evidence that pediatric-onset bipolar disorder comorbid with ADHD represents a distinct subtype: Results from a large controlled family study

Abstract We used familial risk analysis to clarify the diagnostic comorbidity between pediatric BP-I disorder and ADHD, testing the hypothesis that pediatric-BP-I disorder comorbid with ADHD represents a distinct subtype. Structured diagnostic interviews were used to obtain DSM-IV psychiatric diagno...

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Bibliographic Details
Published in:Journal of psychiatric research 2013-01, Vol.47 (1), p.15-22
Main Authors: Biederman, Joseph, Faraone, Stephen V, Petty, Carter, Martelon, MaryKate, Woodworth, K. Yvonne, Wozniak, Janet
Format: Article
Language:English
Subjects:
Adolescent
Adult and adolescent clinical studies
Age of Onset
Attention Deficit Disorder with Hyperactivity - classification
Attention Deficit Disorder with Hyperactivity - epidemiology
Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit disorders. Hyperactivity
Attention deficit hyperactivity disorder
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - classification
Bipolar Disorder - epidemiology
Bipolar Disorder - genetics
Bipolar disorders
Child
Child clinical studies
Children
Comorbidity
Dopamine Plasma Membrane Transport Proteins - genetics
Familial factors
Family-genetic
Female
Genetic Association Studies
Humans
Male
Medical sciences
Middle Aged
Mood disorders
Paediatrics
Pedigree
Prevalence
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Subtypes
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Summary:Abstract We used familial risk analysis to clarify the diagnostic comorbidity between pediatric BP-I disorder and ADHD, testing the hypothesis that pediatric-BP-I disorder comorbid with ADHD represents a distinct subtype. Structured diagnostic interviews were used to obtain DSM-IV psychiatric diagnoses on first-degree relatives ( n  = 726) of referred children and adolescents satisfying diagnostic criteria for BP-I disorder ( n  = 239). For comparison, diagnostic information on the first-degree relatives ( N  = 511) of non-bipolar ADHD children ( N  = 162) and the first degree relatives ( N  = 411) of control children ( N  = 136) with neither ADHD nor BP-I disorder were examined. BP-I disorder and ADHD in probands bred true irrespective of the comorbidity with the other disorder. We also found that the comorbid condition of BP-I disorder plus ADHD also bred true in families, and the two disorders co-segregated among relatives. This large familial risk analysis provides compelling evidence that pediatric BP-I disorder comorbid with ADHD represents a distinct familial subtype.
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2012.08.002