Computational Modeling of Microabscess Formation

Bacterial infections can be of two types: acute or chronic. The chronic bacterial infections are characterized by being a large bacterial infection and/or an infection where the bacteria grows rapidly. In these cases, the immune response is not capable of completely eliminating the infection which m...

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Published in:Computational and mathematical methods in medicine 2012-01, Vol.2012 (2012), p.1-16
Main Authors: Pigozzo, Alexandre Bittencourt, Macedo, Gilson Costa, dos Santos, Rodrigo Weber, Lobosco, Marcelo
Format: Article
Language:English
Subjects:
Abscess - microbiology
Abscess - physiopathology
Algorithms
Apoptosis
Bacterial Infections
Computer Simulation
Cytokines - metabolism
Humans
Immune System
Macrophages - immunology
Macrophages - microbiology
Models, Biological
Models, Theoretical
Neutrophils - immunology
Neutrophils - microbiology
Time Factors
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container_issue 2012
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container_title Computational and mathematical methods in medicine
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creator Pigozzo, Alexandre Bittencourt
Macedo, Gilson Costa
dos Santos, Rodrigo Weber
Lobosco, Marcelo
description Bacterial infections can be of two types: acute or chronic. The chronic bacterial infections are characterized by being a large bacterial infection and/or an infection where the bacteria grows rapidly. In these cases, the immune response is not capable of completely eliminating the infection which may lead to the formation of a pattern known as microabscess (or abscess). The microabscess is characterized by an area comprising fluids, bacteria, immune cells (mainly neutrophils), and many types of dead cells. This distinct pattern of formation can only be numerically reproduced and studied by models that capture the spatiotemporal dynamics of the human immune system (HIS). In this context, our work aims to develop and implement an initial computational model to study the process of microabscess formation during a bacterial infection.
doi_str_mv 10.1155/2012/736394
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subjects Abscess - microbiology
Abscess - physiopathology
Algorithms
Apoptosis
Bacterial Infections
Computer Simulation
Cytokines - metabolism
Humans
Immune System
Macrophages - immunology
Macrophages - microbiology
Models, Biological
Models, Theoretical
Neutrophils - immunology
Neutrophils - microbiology
Time Factors
title Computational Modeling of Microabscess Formation
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