Successful synchronous chemotherapy and radiotherapy followed by consecutive chemotherapy without surgery for primary intracranial choriocarcinoma: A case report

We experienced a rare case of primary intracranial choriocarcinoma treated successfully with synchronous chemotherapy and radiotherapy followed by three consecutive courses of chemotherapy without surgery. A 19-year-old male patient presented with a two-week history of diplopia, headache, nausea and...

Full description

Saved in:
Bibliographic Details
Published in:Oncology letters 2012-12, Vol.4 (6), p.1389-1391
Main Authors: KIM, MINJIN, YUN, JINA, HUR, SOON MI, MOON, JONG JOO, NAM, JAE HYUNG, KIM, SE HYUNG, KIM, HYUN JUNG, KIM, CHAN KYU, PARK, SEONG KYU, HONG, DAE SIK
Format: Article
Language:English
Subjects:
Brain cancer
Case reports
Chemotherapy
Consciousness
consecutive chemotherapies
Medical imaging
Medical prognosis
Metastasis
Mortality
NMR
Nuclear magnetic resonance
Oncology
Patients
Prevention
primary intracranial choriocarcinoma
Radiation therapy
Surgery
synchronous chemotherapy and radiotherapy
Tomography
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We experienced a rare case of primary intracranial choriocarcinoma treated successfully with synchronous chemotherapy and radiotherapy followed by three consecutive courses of chemotherapy without surgery. A 19-year-old male patient presented with a two-week history of diplopia, headache, nausea and vomiting. Neurological examination revealed visual disturbance, bilateral hearing loss, bilateral sixth nerve palsy, left skew deviation, downgaze limitation and clockwise torsional nystagmus on the left upgaze. During image evaluation, the patient suddenly presented with a confused mental status, bradycardia and decreased respiration. An emergency third ventriculostomy was conducted, followed by synchronous ifosfamide, cisplatin and etoposide chemotherapy (ICE; I, 900 mg/m2; C, 20 mg/m2; and E, 60 mg/m2) on days 1-5, and external radiotherapy (whole brain, 30 Gy/15 Fxs; local boost, 30 Gy/15 Fxs) followed again by three consecutive courses of chemotherapy. This therapy resulted in tumor regression by 63% and full improvement in the patient's neurological condition. However, it was difficult to remove the remaining tumor using a surgical approach due to the risk of postoperative hemorrhage and limited access. We planned to observe the remaining mass without surgery. This patient is now alive and the mass size has not changed for 18 months since treatment. This is the first report of the effectiveness of synchronous chemotherapy and radiotherapy followed by consecutive chemotherapy without surgery in a patient with primary intracranial choriocarcinoma.
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2012.901