Is hemojuvelin a possible new player in iron metabolism in hemodialysis patients?

Introduction Hemojuvelin (HJV) is highly expressed in the liver, skeletal muscles, and heart, seems to play a role in iron absorption and release from cells, and has anti-inflammatory properties. Moreover, HJV plays an essential role in the regulation of hepcidin expression, specifically in the iron...

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Bibliographic Details
Published in:International urology and nephrology 2012-12, Vol.44 (6), p.1805-1811
Main Authors: Malyszko, J., Malyszko, J. S., Levin-Iaina, N., Koc-Zorawska, E., Kozminski, P., Mysliwiec, M.
Format: Article
Language:English
Subjects:
Antimicrobial Cationic Peptides - blood
Antimicrobial Cationic Peptides - physiology
GPI-Linked Proteins - blood
GPI-Linked Proteins - physiology
Hemochromatosis Protein
Hepcidins
Humans
Iron - metabolism
Medicine
Medicine & Public Health
Middle Aged
Nephrology
Nephrology - Original Paper
Renal Dialysis
Urology
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Summary:Introduction Hemojuvelin (HJV) is highly expressed in the liver, skeletal muscles, and heart, seems to play a role in iron absorption and release from cells, and has anti-inflammatory properties. Moreover, HJV plays an essential role in the regulation of hepcidin expression, specifically in the iron-sensing pathway. Hepcidin has emerged as a key regulator of iron homeostasis. In this study we tested for the first time the hypothesis that HJV is related to iron metabolism in hemodialysis (HD) patients. Methods Iron status, complete blood count, and serum creatinine, albumin, and lipids were assessed, using standard laboratory methods. Serum levels of soluble transferrin receptor (sTFR), high-sensitivity CRP, IL-6, hepcidin, and HJV were measured using commercially available kits. Results Serum HJV, hepcidin, ferritin, IL-6, hsCRP, and serum creatinine were significantly higher (all P  
ISSN:0301-1623
1573-2584
DOI:10.1007/s11255-011-0084-x