Bone Morphogenetic Proteins in Craniofacial Surgery : Current Techniques, Clinical Experiences, and the Future of Personalized Stem Cell Therapy

Critical-size osseous defects cannot heal without surgical intervention and can pose a significant challenge to craniofacial reconstruction. Autologous bone grafting is the gold standard for repair but is limited by a donor site morbidity and a potentially inadequate supply of autologous bone. Alter...

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Bibliographic Details
Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-14
Main Authors: Chenard, Kristofer E., Teven, Chad M., He, Tong-Chuan, Reid, Russell R.
Format: Article
Language:English
Subjects:
Animals
Autografts
Bone Morphogenetic Proteins - therapeutic use
Clinical Trials as Topic - trends
Colleges & universities
Defects
Face - surgery
Fractures
Gene therapy
Humans
Hydroxyapatite
Infections
Morbidity
Patients
Pediatrics
Precision Medicine - trends
Proteins
Review
Skull - surgery
Stem Cell Transplantation - trends
Stem cells
Surgery
Wound healing
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Description
Summary:Critical-size osseous defects cannot heal without surgical intervention and can pose a significant challenge to craniofacial reconstruction. Autologous bone grafting is the gold standard for repair but is limited by a donor site morbidity and a potentially inadequate supply of autologous bone. Alternatives to autologous bone grafting include the use of alloplastic and allogenic materials, mesenchymal stem cells, and bone morphogenetic proteins. Bone morphogenetic proteins (BMPs) are essential mediators of bone formation involved in the regulation of differentiation of osteoprogenitor cells into osteoblasts. Here we focus on the use of BMPs in experimental models of craniofacial surgery and clinical applications of BMPs in the reconstruction of the cranial vault, palate, and mandible and suggest a model for the use of BMPs in personalized stem cell therapies.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2012/601549