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Guide-star-based computational adaptive optics for broadband interferometric tomography

We present a method for the numerical correction of optical aberrations based on indirect sensing of the scattered wavefront from point-like scatterers ("guide stars") within a three-dimensional broadband interferometric tomogram. This method enables the correction of high-order monochroma...

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Bibliographic Details
Published in:Applied physics letters 2012-11, Vol.101 (22), p.221117-221117
Main Authors: Adie, Steven G, Shemonski, Nathan D, Graf, Benedikt W, Ahmad, Adeel, Scott Carney, P, Boppart, Stephen A
Format: Article
Language:English
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Summary:We present a method for the numerical correction of optical aberrations based on indirect sensing of the scattered wavefront from point-like scatterers ("guide stars") within a three-dimensional broadband interferometric tomogram. This method enables the correction of high-order monochromatic and chromatic aberrations utilizing guide stars that are revealed after numerical compensation of defocus and low-order aberrations of the optical system. Guide-star-based aberration correction in a silicone phantom with sparse sub-resolution-sized scatterers demonstrates improvement of resolution and signal-to-noise ratio over a large isotome. Results in highly scattering muscle tissue showed improved resolution of fine structure over an extended volume. Guide-star-based computational adaptive optics expands upon the use of image metrics for numerically optimizing the aberration correction in broadband interferometric tomography, and is analogous to phase-conjugation and time-reversal methods for focusing in turbid media.
ISSN:0003-6951
1077-3118
0003-6951
DOI:10.1063/1.4768778