Dexmedetomidine versus standard therapy with fentanyl for sedation in mechanically ventilated premature neonates

To compare the efficacy and safety of dexmedetomidine and fentanyl for sedation in mechanically ventilated premature neonates. This was a retrospective, observational case-control study in a level III neonatal intensive care unit. Forty-eight premature neonates requiring mechanical ventilation were...

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Bibliographic Details
Published in:The journal of pediatric pharmacology and therapeutics 2012-07, Vol.17 (3), p.252-262
Main Authors: O'Mara, Keliana, Gal, Peter, Wimmer, John, Ransom, J Laurence, Carlos, Rita Q, Dimaguila, Mary Ann V T, Davanzo, Christie C, Smith, McCrae
Format: Article
Language:English
Subjects:
Clinical Investigation
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Summary:To compare the efficacy and safety of dexmedetomidine and fentanyl for sedation in mechanically ventilated premature neonates. This was a retrospective, observational case-control study in a level III neonatal intensive care unit. Forty-eight premature neonates requiring mechanical ventilation were included. Patients received fentanyl (n=24) or dexmedetomidine (n=24) for pain or sedation. Each group also received fentanyl and lorazepam boluses as needed for agitation. The primary outcomes were efficacy and frequency of acute adverse events associated with each drug. Days on mechanical ventilation, stooling patterns, feeding tolerance, and neurologic outcomes were also evaluated. There were no significant differences in baseline demographics between the dexmedetomidine and fentanyl patients. Patients in the dexmedetomidine group required less adjunctive sedation and had more days free of additional sedation in comparison to fentanyl (54.1% vs. 16.5%, p
ISSN:1551-6776
1551-6776
DOI:10.5863/1551-6776-17.3.252