Questionnaire for impulsive-compulsive disorders in Parkinson's Disease-Rating Scale

• Published in: Movement disorders 2012-02, Vol.27 (2), p.242-247
• Main Authors: Weintraub, Daniel, Mamikonyan, Eugenia, Papay, Kimberly, Shea, Judith A., Xie, Sharon X., Siderowf, Andrew
• Format: Article
• Language: English
• Subjects: Aged; Area Under Curve; Biological and medical sciences; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Discriminant Analysis; dopamine agonists; Female; Humans; impulse control disorder; Impulsive Behavior - diagnosis; Impulsive Behavior - etiology; Male; Medical sciences; Middle Aged; Neurology; Parkinson Disease - complications; Parkinson Disease - diagnosis; Parkinson's disease; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index; Surveys and Questionnaires
• ISSN: 0885-3185; 1531-8257
• DOI: 10.1002/mds.24023

Impulse control disorders and related disorders (hobbyism‐punding and dopamine dysregulation syndrome) occur in 15% to 20% of Parkinson's disease (PD) patients. We assessed the validity and reliability of the Questionnaire for Impulsive‐Compulsive Disorders in Parkinson's Disease–Rating Scale (QUIP‐RS), a rating scale designed to measure severity of symptoms and support a diagnosis of impulse control disorders and related disorders in PD. A convenience sample of PD patients at a movement disorders clinic self‐completed the QUIP‐RS and were administered a semistructured diagnostic interview by a blinded trained rater to assess discriminant validity for impulse control disorders (n = 104) and related disorders (n = 77). Subsets of patients were assessed to determine interrater reliability (n = 104), retest reliability (n = 63), and responsiveness to change (n = 29). Adequate cutoff points (both sensitivity and specificity values >80% plus acceptable likelihood ratios) were established for each impulse control disorder and hobbyism‐punding. Interrater and retest reliability (intraclass correlation coefficient r) were >0.60 for all disorders. Participants in an impulse control disorder treatment study who experienced full (t = 3.65, P = .004) or partial (t = 2.98, P = .01) response demonstrated significant improvement on the rating scale over time, while nonresponders did not (t = 0.12, P = .91). The QUIP‐RS appears to be valid and reliable as a rating scale for impulse control disorders and related disorders in PD. Preliminary results suggest that it can be used to support a diagnosis of these disorders, as well as to monitor changes in symptom severity over time. © 2011 Movement Disorder Society