Ion, X-ray, UV and Neutron Microbeam Systems for Cell Irradiation

The array of microbeam cell-irradiation systems, available to users at the Radiological Research Accelerator Facility (RARAF), Center for Radiological Research, Columbia University, is expanding. The HVE 5MV Singletron particle accelerator at the facility provides particles to two focused ion microb...

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Bibliographic Details
Published in:AIP conference proceedings 2010-08, Vol.1336 (1), p.351-355
Main Authors: Bigelow, A W, Randers-Pehrson, G, Garty, G, Geard, C R, Xu, Y, Harken, A D, Johnson, G W, Brenner, D J
Format: Article
Language:English
Subjects:
ACCELERATOR FACILITIES
ACCELERATORS
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
BARYON REACTIONS
BARYONS
BEAMS
BERYLLIUM 7
BERYLLIUM ISOTOPES
BETA DECAY RADIOISOTOPES
CHARGED PARTICLES
CHARGED-PARTICLE REACTIONS
DAYS LIVING RADIOISOTOPES
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
ELECTROSTATIC ACCELERATORS
ELEMENTARY PARTICLES
EMISSION
ENERGY-LEVEL TRANSITIONS
EVEN-ODD NUCLEI
EXCITATION
FERMIONS
HADRON REACTIONS
HADRONS
INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY
IONIZING RADIATIONS
IONS
IRRADIATION
ISOTOPES
LIGHT NUCLEI
LITHIUM 7 TARGET
MICROSCOPES
MULTI-PHOTON PROCESSES
NEUTRON BEAMS
NEUTRON EMISSION
NEUTRONS
NUCLEAR REACTIONS
NUCLEI
NUCLEON BEAMS
NUCLEON REACTIONS
NUCLEONS
PARTICLE BEAMS
PROTON REACTIONS
RADIATIONS
RADIOISOTOPES
SYMMETRY
TARGETS
X RADIATION
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Summary:The array of microbeam cell-irradiation systems, available to users at the Radiological Research Accelerator Facility (RARAF), Center for Radiological Research, Columbia University, is expanding. The HVE 5MV Singletron particle accelerator at the facility provides particles to two focused ion microbeam lines: the sub-micron microbeam II and the permanent magnetic microbeam (PMM). Both the electrostatic quadrupole lenses on the microbeam II system and the magnetic quadrupole lenses on the PMM system are arranged as compound lenses consisting of two quadrupole triplets with "Russian" symmetry. Also, the RARAF accelerator is a source for a proton-induced x-ray microbeam (undergoing testing) and is projected to supply protons to a neutron microbeam based on the (7)Li(p, n)(7)Be nuclear reaction (under development). Leveraging from the multiphoton microscope technology integrated within the microbeam II endstation, a UV microspot irradiator - based on multiphoton excitation - is available for facility users. Highlights from radiation-biology demonstrations on single living mammalian cells are included in this review of microbeam systems for cell irradiation at RARAF.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.3586118