Substituted 1,3,5-Triazaadamantanes: Biocompatible and Degradable Building Blocks

Basic groups from acid hydrolysis: 1,3,5‐Triazaadamantanes (TAAs) are shown to degrade in acidic conditions to produce basic byproducts (see scheme). The rate of hydrolysis can be tuned by changing the substituents present on the aromatic rings. TAA‐containing dendrimers can be synthesized readily a...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2008-01, Vol.47 (42), p.8072-8074
Main Authors: Balija, Amy M, Kohman, Richie E, Zimmerman, Steven C
Format: Article
Language:English
Subjects:
Adamantane - chemical synthesis
Adamantane - chemistry
Aza Compounds - chemical synthesis
Aza Compounds - chemistry
Biocompatible Materials - chemical synthesis
Biocompatible Materials - chemistry
Crystallography, X-Ray
degradation
dendrimers
Dendrimers - chemistry
host-guest systems
hydrolysis
macromolecules
Models, Molecular
Molecular Structure
Spectrometry, Fluorescence
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Summary:Basic groups from acid hydrolysis: 1,3,5‐Triazaadamantanes (TAAs) are shown to degrade in acidic conditions to produce basic byproducts (see scheme). The rate of hydrolysis can be tuned by changing the substituents present on the aromatic rings. TAA‐containing dendrimers can be synthesized readily as a result of the branched architecture of the TAA building blocks.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200802222