The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo

Reciprocal inductive interactions between the embryonic and extraembryonic tissues establish the anterior-posterior (AP) axis of the early mouse embryo. The anterior visceral endoderm (AVE) signaling center emerges at the distal tip of the embryo at embryonic day 5.5 and translocates to the prospect...

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Bibliographic Details
Published in:Genes & development 2013-05, Vol.27 (9), p.997-1002
Main Authors: Nowotschin, Sonja, Costello, Ita, Piliszek, Anna, Kwon, Gloria S, Mao, Chai-an, Klein, William H, Robertson, Elizabeth J, Hadjantonakis, Anna-Katerina
Format: Article
Language:English
Subjects:
Animals
Body Patterning - genetics
Cell Line
Embryo, Mammalian
Endoderm - metabolism
Gene Expression Regulation, Developmental
LIM-Homeodomain Proteins - genetics
LIM-Homeodomain Proteins - metabolism
Mice
Mutation
Research Communication
T-Box Domain Proteins - genetics
T-Box Domain Proteins - metabolism
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Reciprocal inductive interactions between the embryonic and extraembryonic tissues establish the anterior-posterior (AP) axis of the early mouse embryo. The anterior visceral endoderm (AVE) signaling center emerges at the distal tip of the embryo at embryonic day 5.5 and translocates to the prospective anterior side of the embryo. The process of AVE induction and migration are poorly understood. Here we demonstrate that the T-box gene Eomesodermin (Eomes) plays an essential role in AVE recruitment, in part by directly activating the homeobox transcription factor Lhx1. Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP identity.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.215152.113